UniProt Accession

 SGCB_HUMAN; Q16585; O00661 

Genbank Protein ID

 U31116; U29586; U63801; U63796; U63797; U63798; U63800; Y09781; BC020709 

Genbank Nucleotide ID

 AAA87034.1; AAB41291.1; AAB46956.1; AAB46956.1; AAB46956.1; AAB46956.1; AAB46956.1; CAA70920.1; AAH20709.1 

Protein Name

 Beta-sarcoglycan 

Protein Synonyms/Alias

 Beta-SG; 43 kDa dystrophin-associated glycoprotein; 43DAG; A3b 

Gene Name

 SGCB 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
41	KEHNSNFKAGYIPID	ubiquitination	[1]
111	ESGLLRFKQVSDMGV	ubiquitination	[1, 2, 3]
124	GVIHPLYKSTVGGRR	ubiquitination	[1, 2, 3]
152	VFQQGTTKLSVENNK	ubiquitination	[1]
196	FHLPSGVKSLNVQKA	ubiquitination	[1, 2, 3]
202	VKSLNVQKASTERIT	ubiquitination	[1, 2, 3]
219	ATSDLNIKVDGRAIV	ubiquitination	[1]
286	SGDWVRYKLCMCADG	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. 

Sequence Annotation

 CARBOHYD 158 158 N-linked (GlcNAc...).
 CARBOHYD 211 211 N-linked (GlcNAc...).
 CARBOHYD 258 258 N-linked (GlcNAc...) (Potential).
 DISULFID 288 314 Potential.
 DISULFID 290 307 Potential.  

Keyword

 Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Limb-girdle muscular dystrophy; Membrane; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 318 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0016012; C:sarcoglycan complex; TAS:ProtInc.
 GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
 GO:0035051; P:cardiocyte differentiation; IEA:Compara.
 GO:0007010; P:cytoskeleton organization; IEA:InterPro.
 GO:0007517; P:muscle organ development; TAS:ProtInc. 

Interpro

 IPR006875; Sarcoglycan. 

Pfam

 PF04790; Sarcoglycan_1 

SMART

  

PROSITE

  

PRINTS