CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015807
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 NACHT, LRR and PYD domains-containing protein 9 
Protein Synonyms/Alias
 Nucleotide-binding oligomerization domain protein 6; PYRIN and NACHT-containing protein 12 
Gene Name
 NLRP9 
Gene Synonyms/Alias
 NALP9; NOD6; PAN12 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
303LGFSESEKKSYFSYFacetylation[1]
304GFSESEKKSYFSYFFacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Involved in inflammation (Potential). 
Sequence Annotation
 DOMAIN 1 94 DAPIN.
 DOMAIN 146 465 NACHT.
 REPEAT 743 763 LRR 1.
 REPEAT 772 793 LRR 2.
 REPEAT 800 820 LRR 3.
 REPEAT 829 850 LRR 4.
 REPEAT 857 877 LRR 5.
 REPEAT 886 907 LRR 6.
 NP_BIND 152 159 ATP (Potential).  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Leucine-rich repeat; Nucleotide-binding; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 991 AA 
Protein Sequence
MAESFFSDFG LLWYLKELRK EEFWKFKELL KQPLEKFELK PIPWAELKKA SKEDVAKLLD 60
KHYPGKQAWE VTLNLFLQIN RKDLWTKAQE EMRNKLNPYR KHMKETFQLI WEKETCLHVP 120
EHFYKETMKN EYKELNDAYT AAARRHTVVL EGPDGIGKTT LLRKVMLDWA EGNLWKDRFT 180
FVFFLNVCEM NGIAETSLLE LLSRDWPESS EKIEDIFSQP ERILFIMDGF EQLKFNLQLK 240
ADLSDDWRQR QPMPIILSSL LQKKMLPESS LLIALGKLAM QKHYFMLRHP KLIKLLGFSE 300
SEKKSYFSYF FGEKSKALKV FNFVRDNGPL FILCHNPFTC WLVCTCVKQR LERGEDLEIN 360
SQNTTYLYAS FLTTVFKAGS QSFPPKVNRA RLKSLCALAA EGIWTYTFVF SHGDLRRNGL 420
SESEGVMWVG MRLLQRRGDC FAFMHLCIQE FCAAMFYLLK RPKDDPNPAI GSITQLVRAS 480
VVQPQTLLTQ VGIFMFGIST EEIVSMLETS FGFPLSKDLK QEITQCLESL SQCEADREAI 540
AFQELFIGLF ETQEKEFVTK VMNFFEEVFI YIGNIEHLVI ASFCLKHCQH LTTLRMCVEN 600
IFPDDSGCIS DYNEKLVYWR ELCSMFITNK NFQILDMENT SLDDPSLAIL CKALAQPVCK 660
LRKLIFTSVY FGHDSELFKA VLHNPHLKLL SLYGTSLSQS DIRHLCETLK HPMCKIEELI 720
LGKCDISSEV CEDIASVLAC NSKLKHLSLV ENPLRDEGMT LLCEALKHSH CALERLMLMY 780
CCLTSVSCDS ISEVLLCSKS LSLLDLGSNA LEDNGVASLC AALKHPGCSI RELWLMGCFL 840
TSDSCKDIAA VLICNGKLKT LKLGHNEIGD TGVRQLCAAL QHPHCKLECL GLQTCPITRA 900
CCDDIAAALI ACKTLRSLNL DWIALDADAV VVLCEALSHP DCALQMLGLH KSGFDEETQK 960
ILMSVEEKIP HLTISHGPWI DEEYKIRGVL L 991 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW. 
Interpro
 IPR004020; DAPIN.
 IPR011029; DEATH-like_dom.
 IPR007111; NACHT_NTPase.
 IPR027417; P-loop_NTPase. 
Pfam
 PF02758; PYRIN 
SMART
  
PROSITE
 PS50824; DAPIN
 PS50837; NACHT 
PRINTS