UniProt Accession

 NUDT5_MOUSE; Q9JKX6; A2ATT6; Q99KM4 

Genbank Protein ID

 AF222786; AK088222; AL928924; BC004571; BC049595 

Genbank Nucleotide ID

 AAF44630.1; BAC40220.1; CAM20348.1; AAH04571.1; AAH49595.1 

Protein Name

 ADP-sugar pyrophosphatase 

Protein Synonyms/Alias

 8-oxo-dGDP phosphatase; Nucleoside diphosphate-linked moiety X motif 5; Nudix motif 5 

Gene Name

 Nudt5 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
26	EELISEGKWVKFEKT	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Hydrolyzes with similar activities ADP-ribose and ADP- mannose. Can also hydrolyzes ADP-glucose (40% of ADP-ribose activity) and other nucleotide sugars with low activity (10%). Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. 

Sequence Annotation

 DOMAIN 56 196 Nudix hydrolase.
 REGION 45 46 Substrate binding; shared with dimeric
 MOTIF 96 117 Nudix box.
 METAL 95 95 Magnesium 1; via carbonyl oxygen (By
 METAL 111 111 Magnesium 2 (By similarity).
 METAL 111 111 Magnesium 3 (By similarity).
 METAL 115 115 Magnesium 1 (By similarity).
 METAL 115 115 Magnesium 3 (By similarity).
 METAL 165 165 Magnesium 3 (By similarity).
 BINDING 27 27 Substrate (By similarity).
 BINDING 83 83 Substrate (By similarity).
 BINDING 97 97 Substrate; via amide nitrogen (By
 BINDING 132 132 Substrate (By similarity).
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 9 9 Phosphoserine.
 MOD_RES 10 10 Phosphoserine.
 MOD_RES 209 209 N6-acetyllysine (By similarity).
 MOD_RES 217 217 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Hydrolase; Magnesium; Metal-binding; Phosphoprotein; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 218 AA 

Protein Sequence

Gene Ontology

 GO:0047631; F:ADP-ribose diphosphatase activity; IEA:EC.
 GO:0019144; F:ADP-sugar diphosphatase activity; ISS:UniProtKB.
 GO:0000287; F:magnesium ion binding; ISS:UniProtKB.
 GO:0017110; F:nucleoside-diphosphatase activity; IDA:MGI.
 GO:0030515; F:snoRNA binding; IDA:UniProtKB.
 GO:0009191; P:ribonucleoside diphosphate catabolic process; ISS:UniProtKB. 

Interpro

 IPR020476; Nudix_hydrolase.
 IPR020084; NUDIX_hydrolase_CS.
 IPR000086; NUDIX_hydrolase_dom.
 IPR015797; NUDIX_hydrolase_dom-like. 

Pfam

 PF00293; NUDIX 

SMART

  

PROSITE

 PS51462; NUDIX
 PS00893; NUDIX_BOX 

PRINTS

 PR00502; NUDIXFAMILY.