UniProt Accession

 NHP2_YEAST; P32495; D6VRE6 

Genbank Protein ID

 X57714; X99000; Z74256; BK006938 

Genbank Nucleotide ID

 CAA40885.1; CAA67483.1; CAA98786.1; DAA11656.1 

Protein Name

 H/ACA ribonucleoprotein complex subunit 2 

Protein Synonyms/Alias

 H/ACA snoRNP protein NHP2; High mobility group-like nuclear protein 2 

Gene Name

 NHP2 

Gene Synonyms/Alias

 YDL208W; D1045 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
15	HKESKESKTVDNYEA	acetylation	[1]
32	PAVLPFAKPLASKKL	ubiquitination	[2]
117	LGAAGATKRPTSVVF	acetylation	[1]
143	KNKEEEYKESFNEVV	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. Essential for growth. Directly binds H/ACA snoRNAs. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis; RNA-binding; rRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 156 AA 

Protein Sequence

Gene Ontology

 GO:0031429; C:box H/ACA snoRNP complex; IPI:SGD.
 GO:0030515; F:snoRNA binding; IDA:UniProtKB.
 GO:0000469; P:cleavage involved in rRNA processing; IMP:SGD.
 GO:0031118; P:rRNA pseudouridine synthesis; IMP:SGD.
 GO:0031120; P:snRNA pseudouridine synthesis; IDA:SGD. 

Interpro

 IPR002415; H/ACA_rnp_Nhp2_euk.
 IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
 IPR018492; Ribosomal_L7Ae/L8/Nhp2.
 IPR004037; Ribosomal_L7Ae_CS. 

Pfam

 PF01248; Ribosomal_L7Ae 

SMART

  

PROSITE

 PS01082; RIBOSOMAL_L7AE 

PRINTS

 PR00881; L7ARS6FAMILY.
 PR00883; NUCLEARHMG.