| Tag | Content |
|---|
| CPLM ID | CPLM-009085 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Receptor-interacting serine/threonine-protein kinase 4 |
Protein Synonyms/Alias | Ankyrin repeat domain-containing protein 3; PKC-delta-interacting protein kinase |
Gene Name | RIPK4 |
Gene Synonyms/Alias | ANKRD3; DIK |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 51 | WKTWLAIKCSPSLHV | ubiquitination | [1] | | 145 | PLLHLDLKPANILLD | ubiquitination | [1] |
|
Reference | [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties. Chen Z, Zhou Y, Song J, Zhang Z. Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [ PMID: 23603789] |
Functional Description | Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation. |
Sequence Annotation | DOMAIN 22 286 Protein kinase.
REPEAT 485 514 ANK 1.
REPEAT 518 547 ANK 2.
REPEAT 551 580 ANK 3.
REPEAT 584 613 ANK 4.
REPEAT 617 647 ANK 5.
REPEAT 651 680 ANK 6.
REPEAT 684 713 ANK 7.
REPEAT 717 746 ANK 8.
REPEAT 750 780 ANK 9.
REPEAT 782 811 ANK 10.
NP_BIND 28 36 ATP (By similarity).
ACT_SITE 143 143 Proton acceptor (By similarity).
BINDING 51 51 ATP (By similarity).
CROSSLNK 51 51 Glycyl lysine isopeptide (Lys-Gly)
CROSSLNK 145 145 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Alternative splicing; ANK repeat; ATP-binding; Complete proteome; Cytoplasm; Disease mutation; Isopeptide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 832 AA |
Protein Sequence | MEGDGGTPWA LALLRTFDAG EFTGWEKVGS GGFGQVYKVR HVHWKTWLAI KCSPSLHVDD 60
RERMELLEEA KKMEMAKFRY ILPVYGICRE PVGLVMEYME TGSLEKLLAS EPLPWDLRFR 120
IIHETAVGMN FLHCMAPPLL HLDLKPANIL LDAHYHVKIS DFGLAKCNGL SHSHDLSMDG 180
LFGTIAYLPP ERIREKSRLF DTKHDVYSFA IVIWGVLTQK KPFADEKNIL HIMVKVVKGH 240
RPELPPVCRA RPRACSHLIR LMQRCWQGDP RVRPTFQGNG LNGELIRQVL AALLPVTGRW 300
RSPGEGFRLE SEVIIRVTCP LSSPQEITSE TEDLCEKPDD EVKETAHDLD VKSPPEPRSE 360
VVPARLKRAS APTFDNDYSL SELLSQLDSG VSQAVEGPEE LSRSSSESKL PSSGSGKRLS 420
GVSSVDSAFS SRGSLSLSFE REPSTSDLGT TDVQKKKLVD AIVSGDTSKL MKILQPQDVD 480
LALDSGASLL HLAVEAGQEE CAKWLLLNNA NPNLSNRRGS TPLHMAVERR VRGVVELLLA 540
RKISVNAKDE DQWTALHFAA QNGDESSTRL LLEKNASVNE VDFEGRTPMH VACQHGQENI 600
VRILLRRGVD VSLQGKDAWL PLHYAAWQGH LPIVKLLAKQ PGVSVNAQTL DGRTPLHLAA 660
QRGHYRVARI LIDLCSDVNV CSLLAQTPLH VAAETGHTST ARLLLHRGAG KEAMTSDGYT 720
ALHLAARNGH LATVKLLVEE KADVLARGPL NQTALHLAAA HGHSEVVEEL VSADVIDLFD 780
EQGLSALHLA AQGRHAQTVE TLLRHGAHIN LQSLKFQGGH GPAATLLRRS KT 832 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:UniProtKB. GO:0016020; C:membrane; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. GO:0002009; P:morphogenesis of an epithelium; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |