CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018537
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Formimidoyltransferase-cyclodeaminase 
Protein Synonyms/Alias
 Formiminotransferase-cyclodeaminase; FTCD; Glutamate formimidoyltransferase; Glutamate formiminotransferase; Glutamate formyltransferase; Formimidoyltetrahydrofolate cyclodeaminase; Formiminotetrahydrofolate cyclodeaminase 
Gene Name
 Ftcd 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
77SQLIDMSKHKGEHPRubiquitination[1]
109EECVLCAKAFGQRLAubiquitination[1]
152EYEALPEKLKQAEWVubiquitination[1]
218DQPGRLKKVQGIGWYubiquitination[1]
288AAAFYCDKEKLFVLEubiquitination[1]
290AFYCDKEKLFVLEEEacetylation[2]
290AFYCDKEKLFVLEEEubiquitination[1]
318SLAPFDPKERIIEYLubiquitination[1]
424AACLEAIKLPKNTPEubiquitination[1]
513TDDVFKEKTHHRISSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 
Functional Description
 Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity). 
Sequence Annotation
 REGION 1 181 Formiminotransferase N-subdomain (By
 REGION 163 172 Folate binding (Potential).
 REGION 182 326 Formiminotransferase C-subdomain (By
 REGION 327 334 Linker (By similarity).
 REGION 335 541 Cyclodeaminase/cyclohydrolase (By
 ACT_SITE 82 82 For formimidoyltransferase activity (By
 ACT_SITE 412 412 For cyclodeaminase activity (By
 MOD_RES 519 519 Phosphoserine.  
Keyword
 Complete proteome; Cytoplasm; Cytoskeleton; Folate-binding; Golgi apparatus; Histidine metabolism; Lyase; Multifunctional enzyme; Phosphoprotein; Pyridoxal phosphate; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 541 AA 
Protein Sequence
MSQLVECVPN FSEGNNQEVI DAISRAISQT PGCVLLDVDA GPSTNRTVYT FVGQPECVVE 60
GALHAARTAS QLIDMSKHKG EHPRMGALDV CPFIPVRGVS MEECVLCAKA FGQRLAEELN 120
VPVYLYGEAA QTPSRQTLPA IRAGEYEALP EKLKQAEWVP DFGPSSFVPS WGATVTGARK 180
FLIAFNINLL STKEQAHRIA LNLREQGRGK DQPGRLKKVQ GIGWYLEEKN LAQVSTNLLD 240
FEVTALHTVF EEARREAQEL NLPVVGSQLV GLVPLKALLD AAAFYCDKEK LFVLEEEHRI 300
RLVVNRLGLD SLAPFDPKER IIEYLVPDSG PEQSLLDTSL RGFVREVGAR SAAPGGGSVA 360
AAVAALGAAL ASMVGQMTYG RRQFDHLDST MRRLIPPFHA ASAQLTSLVD ADARAFAACL 420
EAIKLPKNTP EERDRRACAL QEGLRQAVAV PLKLAETVSQ LWPALQELAH CGNLSCLSDL 480
QVAAKALETG VFGAYFNVLI NLKDMTDDVF KEKTHHRISS LLQEAKTQAA LVLGSLEARK 540
E 541 
Gene Ontology
 GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0005542; F:folic acid binding; IEA:UniProtKB-KW.
 GO:0030412; F:formimidoyltetrahydrofolate cyclodeaminase activity; TAS:MGI.
 GO:0030409; F:glutamate formimidoyltransferase activity; TAS:MGI.
 GO:0007010; P:cytoskeleton organization; IEA:Compara.
 GO:0006548; P:histidine catabolic process; TAS:MGI.
 GO:0019556; P:histidine catabolic process to glutamate and formamide; IEA:UniProtKB-UniPathway.
 GO:0019557; P:histidine catabolic process to glutamate and formate; IEA:UniProtKB-UniPathway.
 GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway. 
Interpro
 IPR007044; Cyclodeamin/CycHdrlase.
 IPR013802; Formiminotransferase_C.
 IPR004227; Formiminotransferase_cat.
 IPR012886; Formiminotransferase_N.
 IPR022384; FormiminoTrfase_N/C_subdom. 
Pfam
 PF02971; FTCD
 PF04961; FTCD_C
 PF07837; FTCD_N 
SMART
  
PROSITE
  
PRINTS