Tag | Content |
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CPLM ID | CPLM-004736 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein phosphatase 1 regulatory subunit 1A |
Protein Synonyms/Alias | Protein phosphatase inhibitor 1; I-1; IPP-1 |
Gene Name | Ppp1r1a |
Gene Synonyms/Alias | Ipp1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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82 | TRTTPTMKELQTMVE | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. |
Sequence Annotation | REGION 9 12 Essential for activity. REGION 42 54 Essential for activity (Probable). REGION 143 171 Interaction with PPP1R15A (By MOD_RES 1 1 N-acetylmethionine (By similarity). MOD_RES 35 35 Phosphothreonine; by PKA (By similarity). MOD_RES 67 67 Phosphoserine (By similarity). |
Keyword | Acetylation; Carbohydrate metabolism; Complete proteome; Glycogen metabolism; Phosphoprotein; Protein phosphatase inhibitor; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 171 AA |
Protein Sequence | MEPDNSPRKI QFTVPLLEPH LDPEAAEQIR RRRPTPATLV LTSDQSSPEV DEDRIPNPLL 60 KSTLSMSPRQ RKKMTRTTPT MKELQTMVEH HLGQQKQGEE PEGATESTGN QESCPPGIPD 120 TGSASRPDTS GTAQKPAESK PKTQEQRGVE PSTEDLSAHM LPLDSQGASL V 171 |
Gene Ontology | GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW. GO:0005977; P:glycogen metabolic process; IEA:UniProtKB-KW. GO:0007165; P:signal transduction; IEA:InterPro. |
Interpro | |
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