UniProt Accession

 MDHC_XENLA; Q6PAB3 

Genbank Protein ID

 BC060386 

Genbank Nucleotide ID

 AAH60386.1 

Protein Name

 Malate dehydrogenase, cytoplasmic 

Protein Synonyms/Alias

 Cytosolic malate dehydrogenase 

Gene Name

 mdh1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Xenopus laevis (African clawed frog) 

NCBI Taxa ID

 8355 

Lysine Modification

Position	Peptide	Type	References
236	QRGAAVIKARKLSSA	acetylation	[1]

Reference

 [1] A biotin switch-based proteomics approach identifies 14-3-3ζ as a target of Sirt1 in the metabolic regulation of caspase-2.
 Andersen JL, Thompson JW, Lindblom KR, Johnson ES, Yang CS, Lilley LR, Freel CD, Moseley MA, Kornbluth S.
 Mol Cell. 2011 Sep 2;43(5):834-42. [PMID: 21884983] 

Functional Description

  

Sequence Annotation

 NP_BIND 11 17 NAD (By similarity).
 NP_BIND 129 131 NAD (By similarity).
 ACT_SITE 187 187 Proton acceptor (By similarity).
 BINDING 92 92 Substrate (By similarity).
 BINDING 98 98 Substrate (By similarity).
 BINDING 105 105 NAD (By similarity).
 BINDING 112 112 NAD (By similarity).
 BINDING 131 131 Substrate (By similarity).
 BINDING 162 162 Substrate (By similarity).  

Keyword

 Cytoplasm; NAD; Oxidoreductase; Tricarboxylic acid cycle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 334 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0030060; F:L-malate dehydrogenase activity; IEA:EC.
 GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.
 GO:0006108; P:malate metabolic process; IEA:InterPro.
 GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW. 

Interpro

 IPR001557; L-lactate/malate_DH.
 IPR022383; Lactate/malate_DH_C.
 IPR001236; Lactate/malate_DH_N.
 IPR015955; Lactate_DH/Glyco_Ohase_4_C.
 IPR001252; Malate_DH_AS.
 IPR011274; Malate_DH_NAD-dep_euk.
 IPR010945; Malate_DH_type2.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF02866; Ldh_1_C
 PF00056; Ldh_1_N 

SMART

  

PROSITE

 PS00068; MDH 

PRINTS