CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004518
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 182 
Protein Synonyms/Alias
 Zinc finger protein 21; Zinc finger protein KOX14 
Gene Name
 ZNF182 
Gene Synonyms/Alias
 KOX14; ZNF21 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
228LSLHQRIKNGEKPFEacetylation[1]
232QRIKNGEKPFECTACacetylation[1]
241FECTACRKTFSKKSHacetylation[1]
442CGKTFTQKSNLGVHQubiquitination[2]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 27 98 KRAB.
 ZN_FING 206 228 C2H2-type 1; degenerate.
 ZN_FING 234 256 C2H2-type 2.
 ZN_FING 262 284 C2H2-type 3.
 ZN_FING 290 312 C2H2-type 4.
 ZN_FING 318 340 C2H2-type 5.
 ZN_FING 346 368 C2H2-type 6.
 ZN_FING 374 396 C2H2-type 7.
 ZN_FING 402 424 C2H2-type 8.
 ZN_FING 430 452 C2H2-type 9.
 ZN_FING 458 480 C2H2-type 10.
 ZN_FING 486 508 C2H2-type 11.
 ZN_FING 514 536 C2H2-type 12.
 ZN_FING 542 564 C2H2-type 13.
 ZN_FING 570 592 C2H2-type 14.
 ZN_FING 598 620 C2H2-type 15.  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 639 AA 
Protein Sequence
MTPASASGED SGSFYSWQKA KREQGLVTFE DVAVDFTQEE WQYLNPPQRT LYRDVMLETY 60
SNLVFVGQQV TKPNLILKLE VEECPAEGKI PFWNFPEVCQ VDEQIERQHQ DDQDKCLLMQ 120
VGFSDKKTII TKSARDCHEF GNILHLSTNL VASIQRPDKH ESFGNNMVDN LDLFSRSSAE 180
NKYDNGCAKL FFHTEYEKTN PGMKPYGYKE CGKGLRRKKG LSLHQRIKNG EKPFECTACR 240
KTFSKKSHLI VHWRTHTGEK PFGCTECGKA FSQKSQLIIH LRTHTGERPF ECPECGKAFR 300
EKSTVIIHYR THTGEKPYEC NECGKAFTQK SNLIVHQKTH TGEKTYECTK CGESFIQKLD 360
LIIHHSTHTG KKPHECNECK KTFSDKSTLI IHQRTHTGEK PHKCTECGKS FNEKSTLIVH 420
QRTHTGEKPY ECDVCGKTFT QKSNLGVHQR THSGEKPFEC NECEKAFSQK SYLMLHQRGH 480
TGEKPYECNE CEKAFSQKSY LIIHQRTHTE EKPYKCNECG KAFREKSKLI IHQRIHTGEK 540
PYECPVCWKA FSQKSQLIIH QRTHTGEKPY ACTECGKAFR EKSTFTVHQR THTGEKPYKC 600
TECGKAFTQK SNLIVHQRTH AGKKAHGRGH TRKSKFMAH 639 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS