UniProt Accession

 PURE_ECOLI; P0AG18; P09028; Q2MBQ6 

Genbank Protein ID

 X12982; M19657; U82664; U00096; AP009048 

Genbank Nucleotide ID

 CAA31420.1; AAA24449.1; AAB40276.1; AAC73625.1; BAE76300.1 

Protein Name

 N5-carboxyaminoimidazole ribonucleotide mutase 

Protein Synonyms/Alias

 N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase 

Gene Name

 purE 

Gene Synonyms/Alias

 b0523; JW0512 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
123	VGTLAIGKAGAANAA	acetylation	[1]
142	QILATHDKELHQRLN	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). 

Sequence Annotation

 BINDING 16 16 Substrate.
 BINDING 19 19 Substrate.
 BINDING 46 46 Substrate.  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Isomerase; Purine biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 169 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0034023; F:5-(carboxyamino)imidazole ribonucleotide mutase activity; IDA:EcoCyc.
 GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR024694; N5-CAIR_mutase_PurE.
 IPR000031; N5-CAIR_Mutase_PurE_dom. 

Pfam

 PF00731; AIRC 

SMART

 SM01001; AIRC 

PROSITE

  

PRINTS