CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024484
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Putative gamma-glutamyltranspeptidase 3 
Protein Synonyms/Alias
 GGT 3; Gamma-glutamyltransferase 3; Glutathione hydrolase 3; Putative gamma-glutamyltranspeptidase 3 heavy chain; Putative gamma-glutamyltranspeptidase 3 light chain 
Gene Name
 GGT3P 
Gene Synonyms/Alias
 GGT3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
334RTLLGDPKFVDVTEVubiquitination[1]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors (By similarity). 
Sequence Annotation
 CARBOHYD 95 95 N-linked (GlcNAc...) (Potential).
 CARBOHYD 120 120 N-linked (GlcNAc...) (Potential).
 CARBOHYD 230 230 N-linked (GlcNAc...) (Potential).
 CARBOHYD 266 266 N-linked (GlcNAc...) (Potential).
 CARBOHYD 297 297 N-linked (GlcNAc...) (Potential).
 CARBOHYD 344 344 N-linked (GlcNAc...) (Potential).
 CARBOHYD 510 510 N-linked (GlcNAc...) (Potential).  
Keyword
 Acyltransferase; Complete proteome; Glutathione biosynthesis; Glycoprotein; Hydrolase; Membrane; Reference proteome; Signal-anchor; Transferase; Transmembrane; Transmembrane helix; Zymogen. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 568 AA 
Protein Sequence
MKKKLVVLGL LAVVLVLVIV GLCLWLPSAS KEPDNHVYTR AAVAADAKQC LEIGRDTLRD 60
GGSAVDAAIA ALLCVGLMNA HSMGIGVGLF LTIYNSTTRK AEVINAREVA PRLAFASMFN 120
SSEQSQKGGL SVAVPGEIRG YELAHQRHGR LPWARLFQPS IQLARQGFPV GKGLAAVLEN 180
KRTVIEQQPV LCEVFCRDRK VLREGERLTL PRLADTYEML AIEGAQAFYN GSLMAQIVKD 240
IQAAGGIVTA EDLNNYCAEL IEHPLNISLG DAVLYMPSAR LSGPVLALIL NILKGYNFSR 300
ESVETPEQKG LTYHRIVEAF RFAYAKRTLL GDPKFVDVTE VVRNMTSEFF AAQLRSQISD 360
HTTHPISYYK PEFYTPDDGG TAHLSVVAED GSAVSATSTI NLYFGSKVCS PVSGILFNNM 420
DDFSSPSITN EFGAPPSPAN FIQPGKQPLL SMCPTIMVGQ DGQVRMVVGA AGGTQITTDT 480
ALAIIYNLWF GYDVKRAVEE PRLHNKLLPN VTTVERNIDQ AVTAALETRH HHTQIASTFI 540
AVVQAIVRTA GGWAAASDSR KGGEPAGY 568 
Gene Ontology
 GO:0031362; C:anchored to external side of plasma membrane; TAS:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0003840; F:gamma-glutamyltransferase activity; TAS:UniProtKB.
 GO:0036374; F:glutathione hydrolase activity; IEA:EC.
 GO:0006750; P:glutathione biosynthetic process; IEA:UniProtKB-KW.
 GO:0006749; P:glutathione metabolic process; TAS:UniProtKB.
 GO:0019370; P:leukotriene biosynthetic process; ISS:UniProtKB. 
Interpro
 IPR000101; GGT_peptidase. 
Pfam
 PF01019; G_glu_transpept 
SMART
  
PROSITE
 PS00462; G_GLU_TRANSPEPTIDASE 
PRINTS
 PR01210; GGTRANSPTASE.