UniProt Accession

 FAP20_HUMAN; Q6NZ36; A6PW39; A6PW40; A6PW41; A8MQT6; F2Z2L4; Q6ZT64; Q71M24; Q96ND7 

Genbank Protein ID

 AK055593; AK126870; AF461903; AL590822; CH471183; BC066360; BC078145; BC103992 

Genbank Nucleotide ID

 BAB70965.1; BAC86730.1; AAQ04817.1; EAW56125.1; AAH66360.1; AAI03993.1 

Protein Name

 Fanconi anemia-associated protein of 20 kDa 

Protein Synonyms/Alias

  

Gene Name

 FAAP20 

Gene Synonyms/Alias

 C1orf86; FP7162 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
152	RSCPMCQKEFAPRLT	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1. 

Sequence Annotation

 ZN_FING 144 174 UBZ-type.  

Keyword

 Alternative splicing; Chromosome; Complete proteome; DNA damage; DNA repair; Metal-binding; Nucleus; Polymorphism; Reference proteome; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 180 AA 

Protein Sequence

Gene Ontology

 GO:0044427; C:chromosomal part; IDA:UniProtKB.
 GO:0043240; C:Fanconi anaemia nuclear complex; IDA:UniProtKB.
 GO:0070530; F:K63-linked polyubiquitin binding; IDA:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0036297; P:interstrand cross-link repair; IMP:UniProtKB.
 GO:0019985; P:translesion synthesis; IMP:UniProtKB. 

Interpro

  

Pfam

  

SMART

  

PROSITE

  

PRINTS