CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006868
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ubiquitin carboxyl-terminal hydrolase 13 
Protein Synonyms/Alias
 Deubiquitinating enzyme 13; Ubiquitin thioesterase 13; Ubiquitin-specific-processing protease 13 
Gene Name
 UBP13 
Gene Synonyms/Alias
 YBL067C; YBL0621 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
469NSDSEPSKSKNFISDubiquitination[1]
571KRFKYSEKQNCNIKLubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, VillĂ©n J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301
Functional Description
  
Sequence Annotation
 ACT_SITE 149 149 Nucleophile (By similarity).
 ACT_SITE 619 619 Proton acceptor (By similarity).
 MOD_RES 198 198 Phosphoserine.  
Keyword
 Complete proteome; Hydrolase; Phosphoprotein; Protease; Reference proteome; Thiol protease; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 747 AA 
Protein Sequence
MIRRWLTISK SGKKKKAVND TITEEVEKVD FKPVNHDIND ELCYSESSDN PSSSLFVSNL 60
DTKETFLNED NNLQISSGLD YSSETCNQGS NYSQDGIFYI SNAKAINAYG GIITQGPEAP 120
ILAMKVSDSM PYGDGSNKVF GYENFGNTCY CNSVLQCLYN LSSLRENILQ FPKKSRESDQ 180
PRKKEMRGKK PRIFTEASFE KSIAGTNGHL PNPKPQSVDD GKPTPVNSVN SNTAGPSEKK 240
SKFFKSFSAK HVQDNNKKEG SPAILTTGKP SSRPQDAPPL IVETPNEPGA PSRLSFENVT 300
DRPPDVPRKI IVGRVLNYEN PSRGSSNSNN LDLKGESNSS LSTPLDKKDT RRSSSSSQIS 360
PEHRKKSALI RGPVLNIDHS LNGSDKATLY SSLRDIFECI TENTYLTGVV SPSSFVDVLK 420
RENVLFNTTM HQDAHEFFNF LLNELSEYIE RENKKIAASD INSDSEPSKS KNFISDLFQG 480
TLTNQIKCLT CDNITSRDEP FLDFPIEVQG DEETDIQEIL KSYHQREMLN GSNKFYCDEC 540
CGLQEAERLV GLKQLPDTLT LHLKRFKYSE KQNCNIKLFN NIHYPLTLNV CSSINSKVCQ 600
KYELAGIVVH MGGGPQHGHY VSLCKHEKFG WLLFDDETVE AVKEETVLEF TGESPNMATA 660
YVLFYKAMYS NAVEKNDREN MAKEQDDNID NLIKYDDWLR TCNSGQKKKE ELPIADDLDT 720
AIDDSFVSNT PIKSSKKKSR MFSFRKS 747 
Gene Ontology
 GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
 GO:0004843; F:ubiquitin-specific protease activity; TAS:SGD.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 
Interpro
 IPR018200; Pept_C19ubi-hydrolase_C_CS.
 IPR001394; Peptidase_C19. 
Pfam
 PF00443; UCH 
SMART
  
PROSITE
 PS00972; UCH_2_1
 PS00973; UCH_2_2
 PS50235; UCH_2_3 
PRINTS