UniProt Accession

 UDP_ECOLI; P12758; Q2M8D6 

Genbank Protein ID

 X15689; M87049; U00096; AP009048 

Genbank Nucleotide ID

 CAA33724.1; AAA67626.1; AAC76834.1; BAE77470.1 

Protein Name

 Uridine phosphorylase 

Protein Synonyms/Alias

 UPase; UrdPase 

Gene Name

 udp 

Gene Synonyms/Alias

 b3831; JW3808 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
3	*****MSKSDVFHLG	acetylation	[1, 2]
13	VFHLGLTKNDLQGAT	acetylation	[1, 2]
33	GDPDRVEKIAALMDK	acetylation	[2]
40	KIAALMDKPVKLASH	acetylation	[1, 2]
43	ALMDKPVKLASHREF	acetylation	[1, 2]
235	IPNAETMKQTESHAV	acetylation	[2]
243	QTESHAVKIVVEAAR	acetylation	[1, 2]

Reference

 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Glycosyltransferase; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 253 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0016020; C:membrane; IDA:UniProtKB.
 GO:0004850; F:uridine phosphorylase activity; IEA:EC.
 GO:0009166; P:nucleotide catabolic process; IEA:InterPro.
 GO:0006974; P:response to DNA damage stimulus; IEP:EcoliWiki.
 GO:0044206; P:UMP salvage; IEA:UniProtKB-UniPathway. 

Interpro

 IPR018017; Nucleoside_phosphorylase.
 IPR018016; Nucleoside_phosphorylase_CS.
 IPR000845; Nucleoside_phosphorylase_d.
 IPR010058; Uridine_phosphorylase. 

Pfam

 PF01048; PNP_UDP_1 

SMART

  

PROSITE

 PS01232; PNP_UDP_1 

PRINTS