| Tag | Content |
|---|
| CPLM ID | CPLM-014506 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Keratin, type I cytoskeletal 19 |
Protein Synonyms/Alias | Cytokeratin-19; CK-19; Keratin-19; K19; Type I keratin Ka19 |
Gene Name | Krt19 |
Gene Synonyms/Alias | Ka19; Krt1-19 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 135 | RDYSQYFKTIEDLRD | acetylation | [1] | | 143 | TIEDLRDKILGATIE | acetylation | [1] | | 171 | AADDFRTKFETEQAL | acetylation | [1] | | 211 | EMQIENLKEELAYLK | acetylation | [1] | | 218 | KEELAYLKKNHEEEI | acetylation | [1] | | 373 | YQQLMDIKSRLEQEI | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle (By similarity). |
Sequence Annotation | REGION 1 82 Head.
REGION 83 390 Rod.
REGION 83 118 Coil 1A.
REGION 119 136 Linker 1.
REGION 137 228 Coil 1B.
REGION 229 251 Linker 12.
REGION 247 393 Necessary for interaction with PNN (By
REGION 252 390 Coil 2.
REGION 391 403 Rod-like helical tail.
MOD_RES 35 35 Phosphoserine (By similarity).
MOD_RES 394 394 Phosphotyrosine (By similarity). |
Keyword | Coiled coil; Complete proteome; Direct protein sequencing; Intermediate filament; Keratin; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 403 AA |
Protein Sequence | MTSYSYRQSS AMSSYGGMGG GPVRFGSGGV FRAPSIHGGS GGRGVSVSST RIVSSSSGGY 60
VGGRGGSFSG ALTVTDGLLG GNEKITMQNL NDRLASYLDK VRALEQANGE LEVKIRDWYQ 120
KQGPGPFRDY SQYFKTIEDL RDKILGATIE NSKIVLQIDN ARLAADDFRT KFETEQALRM 180
SVEADINGLR RVLDELTLAR TDLEMQIENL KEELAYLKKN HEEEISALRS QVGGQVSVEV 240
DSTPGIDLAK ILSEMRSQYE AMAEKNRKDA EAWYLTQIDE LNTQVAVHTT QIQINKTEVT 300
ELRRKVQDLE IELQSQLSMK AALEGTVAEI EARYGAQLSH IQGVISSIEV QLSNVRADTE 360
RQNQEYQQLM DIKSRLEQEI ATYRSLLEGQ EAHYNSLSIA KAL 403 |
Gene Ontology | GO:0043034; C:costamere; IEA:Compara. GO:0016010; C:dystrophin-associated glycoprotein complex; IDA:RGD. GO:0005882; C:intermediate filament; IEA:UniProtKB-KW. GO:0042383; C:sarcolemma; IEA:Compara. GO:0030018; C:Z disc; IEA:Compara. GO:0008307; F:structural constituent of muscle; IEA:Compara. GO:0060706; P:cell differentiation involved in embryonic placenta development; IEA:Compara. GO:0043627; P:response to estrogen stimulus; IEA:Compara. GO:0045214; P:sarcomere organization; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |