CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023706
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kelch domain-containing protein 2 
Protein Synonyms/Alias
 Hepatocellular carcinoma-associated antigen 33; Host cell factor homolog LCP; Host cell factor-like protein 1; HCLP-1 
Gene Name
 KLHDC2 
Gene Synonyms/Alias
 HCA33 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
51MFVWGGYKSNQVRGLubiquitination[1]
117HSRGNTNKFYMLDSRubiquitination[1, 2, 3]
147IPPSSKDKLGVWVYKubiquitination[1]
213SQPITTGKAPSPRAAubiquitination[1]
317FNHPYTEKPRLWHTAubiquitination[1]
362LIFSVQPKSLVRLSLubiquitination[1, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Represses CREB3-mediated transcription by interfering with CREB3-DNA binding. 
Sequence Annotation
 REPEAT 43 89 Kelch 1.
 REPEAT 102 155 Kelch 2.
 REPEAT 157 202 Kelch 3.
 REPEAT 229 278 Kelch 4.
 REPEAT 280 329 Kelch 5.
 REPEAT 331 377 Kelch 6.  
Keyword
 Alternative splicing; Complete proteome; Kelch repeat; Nucleus; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 406 AA 
Protein Sequence
MADGNEDLRA DDLPGPAFES YESMELACPA ERSGHVAVSD GRHMFVWGGY KSNQVRGLYD 60
FYLPREELWI YNMETGRWKK INTEGDVPPS MSGSCAVCVD RVLYLFGGHH SRGNTNKFYM 120
LDSRSTDRVL QWERIDCQGI PPSSKDKLGV WVYKNKLIFF GGYGYLPEDK VLGTFEFDET 180
SFWNSSHPRG WNDHVHILDT ETFTWSQPIT TGKAPSPRAA HACATVGNRG FVFGGRYRDA 240
RMNDLHYLNL DTWEWNELIP QGICPVGRSW HSLTPVSSDH LFLFGGFTTD KQPLSDAWTY 300
CISKNEWIQF NHPYTEKPRL WHTACASDEG EVIVFGGCAN NLLVHHRAAH SNEILIFSVQ 360
PKSLVRLSLE AVICFKEMLA NSWNCLPKHL LHSVNQRFGS NNTSGS 406 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. 
Interpro
 IPR015915; Kelch-typ_b-propeller. 
Pfam
  
SMART
  
PROSITE
  
PRINTS