UniProt Accession

 PPB1_HUMAN; P05187; P05188; P06861; Q53S78; Q96DB7 

Genbank Protein ID

 M19159; M13077; M14169; M14170; AC068134; BC009647; BC068501; BC094743; M12551 

Genbank Nucleotide ID

 AAA51710.1; AAC97139.1; AAA51708.1; AAA51709.1; AAY24087.1; AAH09647.1; AAH68501.1; AAH94743.1; AAA51706.1 

Protein Name

 Alkaline phosphatase, placental type 

Protein Synonyms/Alias

 Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1; PLAP-1 

Gene Name

 ALPP 

Gene Synonyms/Alias

 PLAP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
103	FPYVALSKTYNVDKH	ubiquitination	[1]
126	TAYLCGVKGNFQTIG	ubiquitination	[1]
253	GGTRLDGKNLVQEWL	ubiquitination	[1]
262	LVQEWLAKRQGARYV	ubiquitination	[1]
424	NGPGYVLKDGARPDV	ubiquitination	[1]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

  

Sequence Annotation

 ACT_SITE 114 114 Phosphoserine intermediate.
 METAL 64 64 Magnesium (Potential).
 METAL 64 64 Zinc 2 (Potential).
 METAL 333 333 Magnesium (Potential).
 METAL 338 338 Zinc 1 (Potential).
 METAL 342 342 Zinc 1 (Potential).
 METAL 379 379 Zinc 2 (Potential).
 METAL 380 380 Zinc 2 (Potential).
 METAL 454 454 Zinc 1 (Potential).
 LIPID 506 506 GPI-anchor amidated aspartate.
 CARBOHYD 144 144 N-linked (GlcNAc...) (Potential).
 CARBOHYD 271 271 N-linked (GlcNAc...) (Potential).
 DISULFID 143 205
 DISULFID 489 496  

Keyword

 3D-structure; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; GPI-anchor; Hydrolase; Lipoprotein; Magnesium; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 535 AA 

Protein Sequence

Gene Ontology

 GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.
 GO:0009986; C:cell surface; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0004035; F:alkaline phosphatase activity; IDA:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 

Interpro

 IPR017849; Alkaline_Pase-like_a/b/a.
 IPR001952; Alkaline_phosphatase.
 IPR018299; Alkaline_phosphatase_AS.
 IPR017850; Alkaline_phosphatase_core. 

Pfam

 PF00245; Alk_phosphatase 

SMART

 SM00098; alkPPc 

PROSITE

 PS00123; ALKALINE_PHOSPHATASE 

PRINTS

 PR00113; ALKPHPHTASE.