UniProt Accession

 HBA_RAT; P01946; P33583; Q63243; Q80XV2; Q91V15 

Genbank Protein ID

 M17083; X56325; X65495; U29528; BC059150; BC091567; S66657; M32510 

Genbank Nucleotide ID

 AAA41308.1; CAA39764.1; CAA46476.1; AAA99054.1; AAH59150.1; AAH91567.1; AAP13984.1; AAA41315.1 

Protein Name

 Hemoglobin subunit alpha-1/2 

Protein Synonyms/Alias

 Alpha-1/2-globin; Hemoglobin alpha-1/2 chain 

Gene Name

 Hba1 

Gene Synonyms/Alias

 Hba-a1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
12	ADDKTNIKNCWGKIG	acetylation	[1]
17	NIKNCWGKIGGHGGE	acetylation	[1]
41	FAAFPTTKTYFSHID	acetylation	[1]
57	SPGSAQVKAHGKKVA	acetylation	[1]
61	AQVKAHGKKVADALA	acetylation	[1]
62	QVKAHGKKVADALAK	acetylation	[1]
62	QVKAHGKKVADALAK	ubiquitination	[2]
69	KVADALAKAADHVED	acetylation	[1]
91	LSDLHAHKLRVDPVN	acetylation	[1]
91	LSDLHAHKLRVDPVN	ubiquitination	[2]
140	VSTVLTSKYR*****	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Involved in oxygen transport from the lung to the various peripheral tissues. 

Sequence Annotation

 METAL 59 59 Iron (heme distal ligand).
 METAL 88 88 Iron (heme proximal ligand).
 MOD_RES 17 17 N6-acetyllysine (By similarity).  

Keyword

 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport; Polymorphism; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 142 AA 

Protein Sequence

Gene Ontology

 GO:0005833; C:hemoglobin complex; IDA:RGD.
 GO:0001540; F:beta-amyloid binding; IDA:RGD.
 GO:0020037; F:heme binding; IDA:RGD.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0043177; F:organic acid binding; IPI:RGD.
 GO:0019825; F:oxygen binding; IEA:InterPro.
 GO:0005344; F:oxygen transporter activity; IC:RGD.
 GO:0045776; P:negative regulation of blood pressure; IMP:RGD.
 GO:0051291; P:protein heterooligomerization; IDA:RGD.
 GO:0051930; P:regulation of sensory perception of pain; IMP:RGD. 

Interpro

 IPR000971; Globin.
 IPR009050; Globin-like.
 IPR012292; Globin_dom.
 IPR002338; Haemoglobin_a.
 IPR018331; Haemoglobin_alpha_chain.
 IPR002339; Haemoglobin_pi. 

Pfam

 PF00042; Globin 

SMART

  

PROSITE

 PS01033; GLOBIN 

PRINTS

 PR00612; ALPHAHAEM.
 PR00815; PIHAEM.