UniProt Accession

 MOB1A_HUMAN; Q9H8S9; Q53S34; Q9H3T5; Q9HAI0; Q9NVE2 

Genbank Protein ID

 AB016839; AJ577474; AK001650; AK021657; AK023321; AC073263; BC003398 

Genbank Nucleotide ID

 BAB19058.1; CAE12093.1; BAA91810.1; BAB13868.1; BAB14525.1; AAX93060.1; AAH03398.1 

Protein Name

 MOB kinase activator 1A 

Protein Synonyms/Alias

 Mob1 alpha; Mob1A; Mob1 homolog 1B; Mps one binder kinase activator-like 1B 

Gene Name

 MOB1A 

Gene Synonyms/Alias

 C2orf6; MOB4B; MOBK1B; MOBKL1B 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
104	WADGTNIKKPIKCSA	ubiquitination	[1]
142	KIGVPFPKNFMSVAK	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. 

Sequence Annotation

 METAL 79 79 Zinc.
 METAL 84 84 Zinc.
 METAL 161 161 Zinc.
 METAL 166 166 Zinc.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 12 12 Phosphothreonine (By similarity).
 MOD_RES 35 35 Phosphothreonine.
 MOD_RES 74 74 Phosphothreonine; by STK3/MST2.
 MOD_RES 181 181 Phosphothreonine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Metal-binding; Phosphoprotein; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 216 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0035329; P:hippo signaling cascade; IDA:UniProtKB. 

Interpro

 IPR005301; Mob1_phocein. 

Pfam

 PF03637; Mob1_phocein 

SMART

  

PROSITE

  

PRINTS