UniProt Accession

 A1AT5_MOUSE; Q00898; Q3UJ83; Q545P1 

Genbank Protein ID

 M75717; BC061176; AK004999; AK146576 

Genbank Nucleotide ID

 AAC28866.1; AAH61176.1; BAB23733.1; BAE27272.1 

Protein Name

 Alpha-1-antitrypsin 1-5 

Protein Synonyms/Alias

 Alpha-1 protease inhibitor 5; Serine protease inhibitor 1-5; Serine protease inhibitor A1e; Serpin A1e 

Gene Name

 Serpina1e 

Gene Synonyms/Alias

 Dom5; Spi1-5 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
213	ILFKGKWKKPFDPEN	ubiquitination	[1]
214	LFKGKWKKPFDPENT	ubiquitination	[1]
222	PFDPENTKQAEFHVD	ubiquitination	[1]
292	LNKELISKFLLNRRR	acetylation	[2, 3]
292	LNKELISKFLLNRRR	ubiquitination	[1]
347	TEENAPLKLSQAVHK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [3] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
 Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
 Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599] 

Functional Description

 Does not inhibit elastase or chymotrypsin. No target protease has been identified to date. 

Sequence Annotation

 REGION 368 387 RCL.
 CARBOHYD 64 64 N-linked (GlcNAc...).
 CARBOHYD 101 101 N-linked (GlcNAc...) (Potential).
 CARBOHYD 265 265 N-linked (GlcNAc...) (Potential).  

Keyword

 Complete proteome; Glycoprotein; Protease inhibitor; Reference proteome; Secreted; Serine protease inhibitor; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 413 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; IBA:RefGenome.
 GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:RefGenome.
 GO:0030162; P:regulation of proteolysis; IBA:RefGenome.
 GO:0034097; P:response to cytokine stimulus; IDA:MGI.
 GO:0043434; P:response to peptide hormone stimulus; IDA:MGI. 

Interpro

 IPR023795; Protease_inhib_I4_serpin_CS.
 IPR023796; Serpin_dom.
 IPR000215; Serpin_fam. 

Pfam

 PF00079; Serpin 

SMART

 SM00093; SERPIN 

PROSITE

 PS00284; SERPIN 

PRINTS