UniProt Accession

 O08769_RAT; O08769 

Genbank Protein ID

 AABR06033876; AF015194; AY623024; AY623040; D86924; CH473964 

Genbank Nucleotide ID

 AAB71368.1; AAT46041.1; AAT46051.1; BAA19960.1; EDM01643.1 

Protein Name

 Cyclin dependent kinase inhibitor 

Protein Synonyms/Alias

 Cyclin kinase inhibitor; Cyclin-dependent kinase inhibitor 1B; P27 kip1; P27kip1; Protein Cdkn1b 

Gene Name

 Cdkn1b 

Gene Synonyms/Alias

 p27Kip1; rCG_29991 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
25	ARQTEHPKPSACRNL	acetylation	[1]
59	MEEASQRKWNFDFQN	acetylation	[1]
68	NFDFQNHKPLEGRYE	acetylation	[1]
100	RPPKSACKVPAQESL	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Cyclin; Kinase; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 197 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; IEA:Compara.
 GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; IEA:Compara.
 GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
 GO:0048102; P:autophagic cell death; IEA:Compara.
 GO:0008219; P:cell death; IMP:RGD.
 GO:0071236; P:cellular response to antibiotic; IEA:Compara.
 GO:0071285; P:cellular response to lithium ion; IEA:Compara.
 GO:0071407; P:cellular response to organic cyclic compound; IEA:Compara.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:Compara.
 GO:0006917; P:induction of apoptosis; IEA:Compara.
 GO:0048839; P:inner ear development; IEA:Compara.
 GO:0071850; P:mitotic cell cycle arrest; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0030308; P:negative regulation of cell growth; IEA:Compara.
 GO:0051271; P:negative regulation of cellular component movement; IEA:Compara.
 GO:0045736; P:negative regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:Compara.
 GO:0060770; P:negative regulation of epithelial cell proliferation involved in prostate gland development; IEA:Compara.
 GO:0045930; P:negative regulation of mitotic cell cycle; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0031116; P:positive regulation of microtubule polymerization; IEA:Compara.
 GO:0045732; P:positive regulation of protein catabolic process; IEA:Compara.
 GO:0006813; P:potassium ion transport; IEA:Compara.
 GO:0043200; P:response to amino acid stimulus; IEP:RGD.
 GO:0046686; P:response to cadmium ion; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0032355; P:response to estradiol stimulus; IEP:RGD.
 GO:0009749; P:response to glucose stimulus; IEP:RGD.
 GO:0001666; P:response to hypoxia; IEP:RGD.
 GO:0043434; P:response to peptide hormone stimulus; IEP:RGD.
 GO:0007605; P:sensory perception of sound; IEA:Compara. 

Interpro

 IPR003175; CDI. 

Pfam

 PF02234; CDI 

SMART

  

PROSITE

  

PRINTS