UniProt Accession

 OMA1_HUMAN; Q96E52; D3DQ54; Q5T3G6; Q5T3G7; Q5T3G8; Q5T3G9; Q5T3H0; Q8NBB3 

Genbank Protein ID

 AB048348; AL365187; AL365187; AL365187; AL365187; AL365187; AL109845; AL109845; AL365187; AL365187; AL109845; AL109845; AL365187; CH471059; CH471059; CH471059; BC012915; AK091101 

Genbank Nucleotide ID

 BAC79381.1; CAI13522.1; CAI13523.1; CAI13524.1; CAI13525.1; CAI13526.1; CAI13526.1; CAI22238.1; CAI22238.1; CAI13527.1; CAI13527.1; CAI22239.1; CAI22239.1; EAX06631.1; EAX06632.1; EAX06633.1; AAH12915.1; BAC03583.1 

Protein Name

 Metalloendopeptidase OMA1, mitochondrial 

Protein Synonyms/Alias

 Metalloprotease-related protein 1; MPRP-1; Overlapping with the m-AAA protease 1 homolog 

Gene Name

 OMA1 

Gene Synonyms/Alias

 MPRP1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
230	SKLLLLGKEQFRLLS	ubiquitination	[1]
478	PDPRLLFKLSTKHFL	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. 

Sequence Annotation

 ACT_SITE 328 328 By similarity.
 METAL 327 327 Zinc; catalytic (By similarity).
 METAL 331 331 Zinc; catalytic (Probable).
 METAL 392 392 Zinc; catalytic (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Hydrolase; Membrane; Metal-binding; Metalloprotease; Mitochondrion; Mitochondrion inner membrane; Polymorphism; Protease; Reference proteome; Transit peptide; Transmembrane; Transmembrane helix; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 524 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004222; F:metalloendopeptidase activity; IMP:UniProtKB.
 GO:0042407; P:cristae formation; IEA:Compara.
 GO:0002024; P:diet induced thermogenesis; IMP:UniProtKB.
 GO:0097009; P:energy homeostasis; IMP:UniProtKB.
 GO:0006006; P:glucose metabolic process; IMP:UniProtKB.
 GO:0006629; P:lipid metabolic process; IMP:UniProtKB.
 GO:0006515; P:misfolded or incompletely synthesized protein catabolic process; IMP:UniProtKB.
 GO:0034982; P:mitochondrial protein processing; IEA:Compara.
 GO:0010637; P:negative regulation of mitochondrial fusion; IMP:UniProtKB.
 GO:0006950; P:response to stress; IDA:UniProtKB. 

Interpro

 IPR001915; Peptidase_M48. 

Pfam

 PF01435; Peptidase_M48 

SMART

  

PROSITE

 PS00142; ZINC_PROTEASE 

PRINTS