CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008710
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Succinyl-CoA ligase [ADP-forming] subunit alpha, mitochondrial 
Protein Synonyms/Alias
 Succinyl-CoA synthetase subunit alpha; SCS-alpha 
Gene Name
 LSC1 
Gene Synonyms/Alias
 YOR142W; YOR3352W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
26RESIPYDKTIKNLLLacetylation[1]
29IPYDKTIKNLLLPKDacetylation[1]
38LLLPKDTKVIFQGFTacetylation[1]
253IEAAQFLKEYNFSRSacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
  
Sequence Annotation
 ACT_SITE 284 284 Tele-phosphohistidine intermediate (By  
Keyword
 ATP-binding; Complete proteome; GTP-binding; Ligase; Mitochondrion; Nucleotide-binding; Reference proteome; Transit peptide; Tricarboxylic acid cycle. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 329 AA 
Protein Sequence
MLRSTVSKAS LKICRHFHRE SIPYDKTIKN LLLPKDTKVI FQGFTGKQGT FHASISQEYG 60
TNVVGGTNPK KAGQTHLGQP VFASVKDAIK ETGATASAIF VPPPIAAAAI KESIEAEIPL 120
AVCITEGIPQ HDMLYIAEML QTQDKTRLVG PNCPGIINPA TKVRIGIQPP KIFQAGKIGI 180
ISRSGTLTYE AVQQTTKTDL GQSLVIGMGG DAFPGTDFID ALKLFLEDET TEGIIMLGEI 240
GGKAEIEAAQ FLKEYNFSRS KPMPVASFIA GTVAGQMKGV RMGHSGAIVE GSGTDAESKK 300
QALRDVGVAV VESPGYLGQA LLDQFAKFK 329 
Gene Ontology
 GO:0042645; C:mitochondrial nucleoid; IDA:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003878; F:ATP citrate synthase activity; IEA:InterPro.
 GO:0048037; F:cofactor binding; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0004775; F:succinate-CoA ligase (ADP-forming) activity; IMP:SGD.
 GO:0006104; P:succinyl-CoA metabolic process; IDA:SGD.
 GO:0006099; P:tricarboxylic acid cycle; TAS:SGD. 
Interpro
 IPR017440; Cit_synth/succinyl-CoA_lig_AS.
 IPR003781; CoA-bd.
 IPR005810; CoA_lig_alpha.
 IPR005811; CoA_ligase.
 IPR016040; NAD(P)-bd_dom.
 IPR016102; Succinyl-CoA_synth-like. 
Pfam
 PF02629; CoA_binding
 PF00549; Ligase_CoA 
SMART
 SM00881; CoA_binding 
PROSITE
 PS01216; SUCCINYL_COA_LIG_1
 PS00399; SUCCINYL_COA_LIG_2 
PRINTS
 PR01798; SCOASYNTHASE.