CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020975
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-binding cassette sub-family B member 6, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 Abcb6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
464LLNFETVKYYGAEGYubiquitination[1]
482RYREAILKFQGLEWKubiquitination[1]
771AIQASLAKVCTNRTTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis. 
Sequence Annotation
 DOMAIN 265 556 ABC transmembrane type-1.
 DOMAIN 590 824 ABC transporter.
 NP_BIND 623 630 ATP (Potential).  
Keyword
 ATP-binding; Cell membrane; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Golgi apparatus; Membrane; Mitochondrion; Mitochondrion outer membrane; Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 842 AA 
Protein Sequence
MVTVGNYCET EGPAGPAWTQ NGLSPCFFFT LVPSTLLTLG VLALVLVLPR RRREVPAGPE 60
ELSWAAGPRV APYVLQLFLA TLQMALPLAG LAGRVGTARG VRLPGYLLLA SVLESLASVC 120
GLWLLVVERS QARQSLAMGV WMKFRHSLGL LLLWTVTFAA ENLALVSWNS PQWWWARADL 180
GQQVQFGLWV LRYVTSGGLF ILGLWAPGLR PQSYTLHVHE EDQDVGGNQG RSTDRRSTWR 240
DLGRKLRLLS SYLWPRGSPS LQLIVLICLG LMGLERALNV LVPIFYRDIV NLLTAKAPWS 300
SLAWTVTTYV FLKFLQGGGT GSTGFVSNLR TFLWIRVQQF TSRGVELRLF SHLHELSLRW 360
HLGRRTGEVL RIVDRGTSSV TGLLSYLVFS IIPTLADIII GIIYFSMFFN AWFGLIVFLC 420
MSLYLILTIV VTEWRAKFRR DMNTQENATR ARAVDSLLNF ETVKYYGAEG YEVDRYREAI 480
LKFQGLEWKS TASLVVLNQT QNLVIGLGLL AGSLLCAYFV SEQKLQVGDF VLFGTYITQL 540
YMPLNWFGTY YRMIQTNFID MENMFDLLKE ETEVKDVPGA GPLRFHKGRI EFENVHFSYA 600
DGQETLQDVS FTVMPGQTVA LVGPSGAGKS TILRLLFRFY DISSGCIRID GQDISQVTQI 660
SLRSHIGVVP QDTVLFNDTI ANNIRYGRVT AGDSEVEAAA QAAGIHDAIL SFPEGYETQV 720
GERGLKLSGG EKQRVAIART ILKAPDIILL DEATSALDTS NERAIQASLA KVCTNRTTIV 780
IAHRLSTVVN ADQILVIKDG CIIERGRHEA LLSRGGVYAE MWQLQQQGQE TVPEESKPQD 840
TA 842 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IBA:RefGenome.
 GO:0031307; C:integral to mitochondrial outer membrane; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005774; C:vacuolar membrane; IBA:RefGenome.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IBA:RefGenome.
 GO:0015562; F:efflux transmembrane transporter activity; IEA:Compara.
 GO:0020037; F:heme binding; IEA:Compara.
 GO:0015439; F:heme-transporting ATPase activity; IEA:Compara.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0070574; P:cadmium ion transmembrane transport; IBA:RefGenome.
 GO:0071585; P:detoxification of cadmium ion; IBA:RefGenome.
 GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:Compara.
 GO:0043588; P:skin development; IEA:Compara. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR017940; ABC_transporter_type1.
 IPR001140; ABC_transptr_TM_dom.
 IPR011527; ABC_transptrTM_dom_typ1.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00664; ABC_membrane
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS50929; ABC_TM1F
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS