CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036808
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Proprotein convertase subtilisin/kexin type 6 
Protein Synonyms/Alias
  
Gene Name
 PCSK6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
135LRMDPQVKWLQQQEVubiquitination[1]
175WYLHCGDKNSRCRSEubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Protease; Reference proteome; Serine protease. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 955 AA 
Protein Sequence
MPPRAPPAPG PRPPPRAAAA TDTAAGAGGA GGAGGAGGPG FRPLAPRPWR WLLLLALPAA 60
CSPPPRPVYT NHWAVQVLGG PAEADRVAAA HGYLNLGQIG NLEDYYHFYH SKTFKRSTLS 120
SRGPHTFLRM DPQVKWLQQQ EVKRRVKRQV RSDPQALYFN DPIWSNMWYL HCGDKNSRCR 180
SEMNVQAAWK RGYTGKNVVV TILDDGIERN HPDLAPNYDS YASYDVNGND YDPSPRYDAS 240
NENKHGTRCA GEVAASANNS YCIVGIAYNA KIGGIRMLDG DVTDVVEAKS LGIRPNYIDI 300
YSASWGPDDD GKTVDGPGRL AKQAFEYGIK KGRQGLGSIF VWASGNGGRE GDYCSCDGYT 360
NSIYTISVSS ATENGYKPWY LEECASTLAT TYSSGAFYER KIVTTDLRQR CTDGHTGTSV 420
SAPMVAGIIA LALEANSQLT WRDVQHLLVK TSRPAHLKAS DWKVNGAGHK VSHFYGFGLV 480
DAEALVVEAK KWTAVPSQHM CVAASDKRPR SIPLVQVLRT TALTSACAEH SDQRVVYLEH 540
VVVRTSISHP RRGDLQIYLV SPSGTKSQLL AKRLLDLSNE GFTNWEFMTV HCWGEKAEGQ 600
WTLEIQDLPS QVRNPEKQGK LKEWSLILYG TAEHPYHTFS AHQSRSRMLE LSAPELEPPK 660
AALSPSQVEV PEDEEDYTGV CHPECGDKGC DGPNADQCLN CVHFSLGSVK TSRKCVSVCP 720
LGYFGDTAAR RCRRCHKGCE TCSSRAATQC LSCRRGFYHH QEMNTCVTLC PAGFYADESQ 780
KNCLKCHPSC KKCVDEPEKC TVCKEGFSLA RGSCIPDCEP GTYFDSELIR CGECHHTCGT 840
CVGPGREECI HCAKNFHFHD WKCVPACGEG FYPEEMPGLP HKVCRRCDEN CLSCAGSSRN 900
CSRCKTGFTQ LGTSCITNHT CSNADETFCE MVKSNRLCER KLFIQFCCRT CLLAG 955 
Gene Ontology
 GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR006212; Furin_repeat.
 IPR008979; Galactose-bd-like.
 IPR009030; Growth_fac_rcpt_N_dom.
 IPR000209; Peptidase_S8/S53_dom.
 IPR023827; Peptidase_S8_Asp-AS.
 IPR022398; Peptidase_S8_His-AS.
 IPR023828; Peptidase_S8_Ser-AS.
 IPR015500; Peptidase_S8_subtilisin-rel.
 IPR010909; PLAC.
 IPR009020; Prot_inh_propept.
 IPR002884; PrprotnconvertsP. 
Pfam
 PF01483; P_proprotein
 PF00082; Peptidase_S8
 PF08686; PLAC 
SMART
 SM00261; FU 
PROSITE
 PS50900; PLAC
 PS00136; SUBTILASE_ASP
 PS00137; SUBTILASE_HIS
 PS00138; SUBTILASE_SER 
PRINTS
 PR00723; SUBTILISIN.