UniProt Accession

 TP4A3_HUMAN; O75365; Q8IVN5; Q99849; Q9BTW5 

Genbank Protein ID

 AF041434; AJ276554; BT007303; BC003105; U87168 

Genbank Nucleotide ID

 AAC29314.1; CAC81757.1; AAP35967.1; AAH03105.1; AAB47560.1 

Protein Name

 Protein tyrosine phosphatase type IVA 3 

Protein Synonyms/Alias

 PRL-R; Protein-tyrosine phosphatase 4a3; Protein-tyrosine phosphatase of regenerating liver 3; PRL-3 

Gene Name

 PTP4A3 

Gene Synonyms/Alias

 PRL3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
155	YLEKYRPKQRLRFKD	acetylation	[1]
167	FKDPHTHKTRCCVM*	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. 

Sequence Annotation

 DOMAIN 82 148 Tyrosine-protein phosphatase.
 ACT_SITE 72 72 Proton donor (Probable).
 ACT_SITE 104 104 Phosphocysteine intermediate.
 BINDING 110 110 Substrate.
 MOD_RES 170 170 Cysteine methyl ester (By similarity).
 LIPID 170 170 S-farnesyl cysteine (By similarity).
 DISULFID 49 104  

Keyword

 3D-structure; Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; Endosome; Hydrolase; Lipoprotein; Membrane; Methylation; Prenylation; Protein phosphatase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 173 AA 

Protein Sequence

Gene Ontology

 GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0004727; F:prenylated protein tyrosine phosphatase activity; TAS:ProtInc. 

Interpro

 IPR000387; Tyr/Dual-sp_Pase.
 IPR000242; Tyr_Pase_rcpt/non-rcpt. 

Pfam

 PF00102; Y_phosphatase 

SMART

  

PROSITE

 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50055; TYR_PHOSPHATASE_PTP 

PRINTS