CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020813
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Clavesin-1 
Protein Synonyms/Alias
 Retinaldehyde-binding protein 1-like 1 
Gene Name
 Clvs1 
Gene Synonyms/Alias
 Rlbp1l1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
84LRFLRARKFHQADAFubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). 
Sequence Annotation
 DOMAIN 118 279 CRAL-TRIO.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasmic vesicle; Endosome; Golgi apparatus; Lipid-binding; Membrane; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 354 AA 
Protein Sequence
MGPVSVLPSP QSLSTWEGDL AKMTHLQAGL SPDTIEKARL ELNENPDILH QDIQQVRDMI 60
ITRPDIGFLR TDDAFILRFL RARKFHQADA FRLLAQYFQY RQLNLDMFKN FKADDPGIKR 120
ALIDGFPGVL ENRDHYGRKI LLLFAANWDQ SRNSFTDILR AILLSLEVLI EDPELQINGF 180
ILIIDWSNFS FKQASKLTPS ILKLAIEGLQ DSFPARFGGV HFVNQPWYIH ALYTLIKPFL 240
KDKTRKRIFL HGNNLNSLHQ LIHPEFLPSE FGGTLPPYDM GTWARTLLGP DYSDENDYTH 300
TSYNAMHVKH TCSNLERECS PKPMKRSQSV VEAGTLKHEE KGENENTQPL LALD 354 
Gene Ontology
 GO:0030136; C:clathrin-coated vesicle; ISS:UniProtKB.
 GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005768; C:endosome; ISS:UniProtKB.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
 GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; ISS:UniProtKB.
 GO:0005215; F:transporter activity; IEA:InterPro.
 GO:0007040; P:lysosome organization; ISS:UniProtKB. 
Interpro
 IPR001071; CRAL-bd_toc_tran.
 IPR001251; CRAL-TRIO_dom.
 IPR011074; CRAL/TRIO_N_dom. 
Pfam
 PF00650; CRAL_TRIO
 PF03765; CRAL_TRIO_N 
SMART
 SM01100; CRAL_TRIO_N
 SM00516; SEC14 
PROSITE
 PS50191; CRAL_TRIO 
PRINTS
 PR00180; CRETINALDHBP.