UniProt Accession

 DD19B_HUMAN; Q9UMR2; B3KNE9; B4DXS6; E7EMK4; Q6FIB7; Q6IAE0; Q96KE7; Q9H0U0 

Genbank Protein ID

 AJ237946; AF353720; AL136639; CR457215; CR533509; AK027378; AK301938; AK302107; AK316346; AC012184; CH471241; CH471241; CH471241; CH471241; BC003626; BC010008 

Genbank Nucleotide ID

 CAB52189.1; AAK40102.1; CAB66574.1; CAG33496.1; CAG38540.1; BAG51311.1; BAG63358.1; BAG63488.1; BAH14717.1; EAW51827.1; EAW51831.1; EAW51832.1; EAW51834.1; AAH03626.1; AAH10008.1 

Protein Name

 ATP-dependent RNA helicase DDX19B 

Protein Synonyms/Alias

 DEAD box RNA helicase DEAD5; DEAD box protein 19B 

Gene Name

 DDX19B 

Gene Synonyms/Alias

 DBP5; DDX19; TDBP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
64	AAQSLLNKLIRSNLV	ubiquitination	[1, 2]
92	NSPLYSVKSFEELRL	ubiquitination	[1, 2, 3]
187	KVIEQMGKFYPELKL	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins. 

Sequence Annotation

 DOMAIN 125 295 Helicase ATP-binding.
 DOMAIN 306 474 Helicase C-terminal.
 NP_BIND 138 145 ATP.
 REGION 2 300 N-terminal lobe.
 REGION 55 68 N-terminal helix.
 REGION 301 479 C-terminal lobe.
 MOTIF 92 120 Q motif.
 MOTIF 242 245 DEAD box.
 BINDING 119 119 ATP.
 BINDING 429 429 ATP.
 BINDING 432 432 ATP.
 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 3D-structure; Acetylation; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Helicase; Hydrolase; Membrane; mRNA transport; Nuclear pore complex; Nucleotide-binding; Nucleus; Polymorphism; Protein transport; Reference proteome; RNA-binding; Translocation; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 479 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; TAS:ProtInc.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0005643; C:nuclear pore; TAS:ProtInc.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0004386; F:helicase activity; TAS:ProtInc.
 GO:0003723; F:RNA binding; TAS:ProtInc.
 GO:0006406; P:mRNA export from nucleus; TAS:ProtInc.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR014014; RNA_helicase_DEAD_Q_motif. 

Pfam

 PF00270; DEAD
 PF00271; Helicase_C 

SMART

 SM00487; DEXDc
 SM00490; HELICc 

PROSITE

 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER
 PS51195; Q_MOTIF 

PRINTS