CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031012
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dihydropyrimidine dehydrogenase [NADP(+)] 
Protein Synonyms/Alias
 cDNA FLJ53741, moderately similar to Dihydropyrimidine dehydrogenase 
Gene Name
 DPYD 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
26ENNFDDIKHTTLGERubiquitination[1]
44REAMRCLKCADAPCQubiquitination[1]
52CADAPCQKSCPTNLDubiquitination[1, 2, 3, 4]
61CPTNLDIKSFITSIAubiquitination[1]
70FITSIANKNYYGAAKubiquitination[1, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 156 AA 
Protein Sequence
MAPVLSKDSA DIENCEKLEN NFDDIKHTTL GERGALREAM RCLKCADAPC QKSCPTNLDI 60
KSFITSIANK NYYGAAKMIF SDNPLGLTCG MVCPTSDLCV GGCNLYATEE GPINIGGLQQ 120
FATEVNGLLH FQNSVSLWFQ KTANISFLSC GSLQDA 156 
Gene Ontology
 GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
 GO:0016491; F:oxidoreductase activity; IEA:InterPro. 
Interpro
 IPR012285; Fum_reductase_C.
 IPR009051; Helical_ferredxn. 
Pfam
  
SMART
  
PROSITE
  
PRINTS