UniProt Accession

 SPS1_MOUSE; Q8BH69 

Genbank Protein ID

 AK044971; AK053638 

Genbank Nucleotide ID

 BAC32163.1; BAC35456.1 

Protein Name

 Selenide, water dikinase 1 

Protein Synonyms/Alias

 Selenium donor protein 1; Selenophosphate synthase 1 

Gene Name

 Sephs1 

Gene Synonyms/Alias

 Sps1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
16	PETYELDKSFRLTRF	ubiquitination	[1]
27	LTRFTELKGTGCKVP	acetylation	[2, 3]
139	MTDRERDKVIPLIIQ	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Synthesizes selenophosphate from selenide and ATP. 

Sequence Annotation

 NP_BIND 67 69 ATP (By similarity).
 NP_BIND 162 164 ATP; shared with dimeric partner (By
 NP_BIND 267 273 ATP (By similarity).
 ACT_SITE 31 31 Potential.
 BINDING 32 32 ATP (By similarity).
 BINDING 87 87 ATP (By similarity).
 BINDING 110 110 ATP (By similarity).
 MOD_RES 2 2 N-acetylserine (By similarity).  

Keyword

 Acetylation; ATP-binding; Cell membrane; Complete proteome; Kinase; Membrane; Nucleotide-binding; Nucleus; Reference proteome; Selenium; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 392 AA 

Protein Sequence

Gene Ontology

 GO:0031965; C:nuclear membrane; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
 GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
 GO:0004756; F:selenide, water dikinase activity; IEA:EC. 

Interpro

 IPR010918; AIR_synth_C_dom.
 IPR000728; AIR_synth_N_dom.
 IPR016188; PurM_N-like.
 IPR004536; SelD. 

Pfam

 PF00586; AIRS
 PF02769; AIRS_C 

SMART

  

PROSITE

  

PRINTS