CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043678
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Superoxide dismutase [Cu-Zn] 
Protein Synonyms/Alias
  
Gene Name
 SOD1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
12AESNGPVKVWGSIKGubiquitination[1]
18VKVWGSIKGLTEGLHubiquitination[2]
52HFNPLSRKHGGPKDEubiquitination[3]
57SRKHGGPKDEERHVGubiquitination[3]
73LGNVTADKDGVADVSubiquitination[3]
104RTLVVHEKADDLGKGacetylation[4, 5, 6]
104RTLVVHEKADDLGKGubiquitination[1, 3]
118GGNEESTKTGNAGSRubiquitination[3, 7]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [4] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [7] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Copper; Metal-binding; Oxidoreductase; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 135 AA 
Protein Sequence
MATKAESNGP VKVWGSIKGL TEGLHGFHVH EFGDNTAGCT SAGPHFNPLS RKHGGPKDEE 60
RHVGDLGNVT ADKDGVADVS IEDSVISLSG DHCIIGRTLV VHEKADDLGK GGNEESTKTG 120
NAGSRLACGV IGIAQ 135 
Gene Ontology
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004784; F:superoxide dismutase activity; IEA:EC.
 GO:0006801; P:superoxide metabolic process; IEA:InterPro. 
Interpro
 IPR024134; SOD_Cu/Zn_/chaperones.
 IPR018152; SOD_Cu/Zn_BS.
 IPR001424; SOD_Cu_Zn_dom. 
Pfam
 PF00080; Sod_Cu 
SMART
  
PROSITE
 PS00087; SOD_CU_ZN_1
 PS00332; SOD_CU_ZN_2 
PRINTS
 PR00068; CUZNDISMTASE.