UniProt Accession

 CNBP_HUMAN; P62633; A8K7V4; B2RAV9; D3DNB9; D3DNC0; D3DNC1; E9PDR7; P20694; Q4JGY0; Q5QJR0; Q5U0E9; Q6PJI7; Q96NV3 

Genbank Protein ID

 M28372; U19765; AY329622; DQ092367; DQ091187; AK054592; AK292119; AK314380; BT019613; AC108673; AC135587; CH471052; CH471052; CH471052; CH471052; CH471052; CH471052; BC000288; BC014911; BC093058 

Genbank Nucleotide ID

 AAA61975.1; AAA91782.1; AAR89462.1; AAY96755.1; AAY89856.1; BAB70769.1; BAF84808.1; BAG37006.1; AAV38419.1; EAW79271.1; EAW79272.1; EAW79273.1; EAW79274.1; EAW79275.1; EAW79277.1; AAH00288.1; AAH14911.1; AAH93058.1 

Protein Name

 Cellular nucleic acid-binding protein 

Protein Synonyms/Alias

 CNBP; Zinc finger protein 9 

Gene Name

 CNBP 

Gene Synonyms/Alias

 RNF163; ZNF9 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
8	MSSNECFKCGRSGHW	ubiquitination	[1]
65	GESGHLAKDCDLQED	ubiquitination	[1]
103	QCCYNCGKPGHLARD	acetylation	[2]
103	QCCYNCGKPGHLARD	ubiquitination	[1]
118	CDHADEQKCYSCGEF	ubiquitination	[1]
130	GEFGHIQKDCTKVKC	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Single stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression. 

Sequence Annotation

 ZN_FING 4 21 CCHC-type 1.
 ZN_FING 52 69 CCHC-type 2.
 ZN_FING 72 89 CCHC-type 3.
 ZN_FING 96 113 CCHC-type 4.
 ZN_FING 117 134 CCHC-type 5.
 ZN_FING 135 152 CCHC-type 6.
 ZN_FING 156 173 CCHC-type 7.  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; DNA-binding; Endoplasmic reticulum; Metal-binding; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 177 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006695; P:cholesterol biosynthetic process; TAS:ProtInc.
 GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR001878; Znf_CCHC. 

Pfam

 PF00098; zf-CCHC 

SMART

 SM00343; ZnF_C2HC 

PROSITE

 PS50158; ZF_CCHC 

PRINTS