CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010571
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Adenylate cyclase type 5 
Protein Synonyms/Alias
 ATP pyrophosphate-lyase 5; Adenylate cyclase type V; Adenylyl cyclase 5 
Gene Name
 Adcy5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
705GFEDPKDKNAQESANubiquitination[1]
1027KLQATEEKEEMEELQubiquitination[1]
1143LNDSTYDKAGKTHIKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 This is a membrane-bound, calcium-inhibitable adenylyl cyclase. 
Sequence Annotation
 DOMAIN 470 597 Guanylate cyclase 1.
 DOMAIN 1072 1211 Guanylate cyclase 2.
 METAL 475 475 Magnesium 1 (By similarity).
 METAL 475 475 Magnesium 2 (By similarity).
 METAL 476 476 Magnesium 2; via carbonyl oxygen (By
 MOD_RES 8 8 Phosphoserine.
 CARBOHYD 239 239 N-linked (GlcNAc...) (Potential).
 CARBOHYD 834 834 N-linked (GlcNAc...) (Potential).
 CARBOHYD 871 871 N-linked (GlcNAc...) (Potential).
 CARBOHYD 888 888 N-linked (GlcNAc...) (Potential).
 CARBOHYD 973 973 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; ATP-binding; cAMP biosynthesis; Cell projection; Cilium; Coiled coil; Complete proteome; Glycoprotein; Lyase; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1262 AA 
Protein Sequence
MSGSKSVSPP GYAAQTAASP APRGGPEHRA AWGEADSRAN GYPHAPGGST RGSTKRSGGA 60
VTPQQQQRLA SRWRGGDDDE DPPLSGDDPL AGGFGFSFRS KSAWQERGGD DGGRGSRRQR 120
RGAAGGGSTR APPAGGSGSS AAAAAAAGGT EVRPRSVELG LEERRGKGRA AEELEPGTGI 180
VEDGDGSEDG GSSVASGSGT GAVLSLGACC LALLQIFRSK KFPSDKLERL YQRYFFRLNQ 240
SSLTMLMAVL VLVCLVMLAF HAARPPLQIA YLAVLAAAVG VILIMAVLCN RAAFHQDHMG 300
LACYALIAVV LAVQVVGLLL PQPRSASEGI WWTVFFIYTI YTLLPVRMRA AVLSGVLLSA 360
LHLAISLHTN SQDQFLLKQL VSNVLIFSCT NIVGVCTHYP AEVSQRQAFQ ETRECIQARL 420
HSQRENQQQE RLLLSVLPRH VAMEMKADIN AKQEDMMFHK IYIQKHDNVS ILFADIEGFT 480
SLASQCTAQE LVMTLNELFA RFDKLAAENH CLRIKILGDC YYCVSGLPEA RADHAHCCVE 540
MGMDMIEAIS LVREVTGVNV NMRVGIHSGR VHCGVLGLRK WQFDVWSNDV TLANHMEAGG 600
KAGRIHITKA TLNYLNGDYE VEPGCGGDRN AYLKEHSIET FLILSCTQKR KEEKAMIAKM 660
NRQRTNSIGH NPPHWGAERP FYNHLGGNQV SKEMKRMGFE DPKDKNAQES ANPEDEVDEF 720
LGRAIDARSI DRLRSEHVRK FLLTFREPDL EKKYSKQVDD RFGAYVACAS LVFLFICFVQ 780
ITIVPHSLFM LSFYLSCFLL LALVVFVSVI YACVKLFPTP LQTLSRKIVR SKKNSTLVGV 840
FTITLVFLSA FVNMFMCNSK NLVGCLAEEH NITVNQVNAC HVMESAFNYS LGDEQGFCGS 900
PQPNCNFPEY FTYSVLLSLL ACSVFLQISC IGKLVLMLAI EFIYVLIVEV PGVTLFDNAD 960
LLVTANAIDF SNNGTSQCPE HATKVALKVV TPIIISVFVL ALYLHAQQVE STARLDFLWK 1020
LQATEEKEEM EELQAYNRRL LHNILPKDVA AHFLARERRN DELYYQSCEC VAVMFASIAN 1080
FSEFYVELEA NNEGVECLRL LNEIIADFDE IISEDRFRQL EKIKTIGSTY MAASGLNDST 1140
YDKAGKTHIK AIADFAMKLM DQMKYINEHS FNNFQMKIGL NIGPVVAGVI GARKPQYDIW 1200
GNTVNVASRM DSTGVPDRIQ VTTDMYQVLA ANTYQLECRG VVKVKGKGEM MTYFLNGGLG 1260
HDGVVGKLKA GLGVSMELKG LLFHCGEVTP PHNVWGTGTG RRVACAILSP HLHAQRQCPV 1320
RETGLLTREA RGHQARSSGS EQKKIFIK 1348 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:BHF-UCL.
 GO:0072372; C:primary cilium; IDA:UniProtKB.
 GO:0004016; F:adenylate cyclase activity; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0001973; P:adenosine receptor signaling pathway; IGI:MGI.
 GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; IGI:MGI.
 GO:0007195; P:adenylate cyclase-inhibiting dopamine receptor signaling pathway; IGI:MGI.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0007626; P:locomotory behavior; IMP:MGI.
 GO:0050885; P:neuromuscular process controlling balance; IMP:MGI. 
Interpro
 IPR001054; A/G_cyclase.
 IPR018297; A/G_cyclase_CS.
 IPR009398; Adenylate_cyclase-like. 
Pfam
 PF06327; DUF1053
 PF00211; Guanylate_cyc 
SMART
 SM00044; CYCc 
PROSITE
 PS00452; GUANYLATE_CYCLASE_1
 PS50125; GUANYLATE_CYCLASE_2 
PRINTS