CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022148
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glycoprotein integral membrane protein 1 
Protein Synonyms/Alias
  
Gene Name
 GINM1 
Gene Synonyms/Alias
 C6orf72; UNQ710/PRO1361 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
224DEDVLPGKLPETPLRubiquitination[1]
294FFPVSEYKGILQLDKubiquitination[2, 3]
301KGILQLDKVDVIPVTubiquitination[1, 2, 3, 4, 5]
319LYPDGPEKRAENLEDubiquitination[1, 2, 3, 4, 5, 6]
327RAENLEDKTCI****ubiquitination[1, 6, 7]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [7] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
 CARBOHYD 46 46 N-linked (GlcNAc...) (Potential).
 CARBOHYD 64 64 N-linked (GlcNAc...) (Potential).
 CARBOHYD 166 166 N-linked (GlcNAc...) (Potential).
 CARBOHYD 191 191 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 330 AA 
Protein Sequence
MEGAPPGSLA LRLLLFVALP ASGWLTTGAP EPPPLSGAPQ DGIRINVTTL KDDGDISKQQ 60
VVLNITYESG QVYVNDLPVN SGVTRISCQT LIVKNENLEN LEEKEYFGIV SVRILVHEWP 120
MTSGSSLQLI VIQEEVVEID GKQVQQKDVT EIDILVKNRG VLRHSNYTLP LEESMLYSIS 180
RDSDILFTLP NLSKKESVSS LQTTSQYLIR NVETTVDEDV LPGKLPETPL RAEPPSSYKV 240
MCQWMEKFRK DLCRFWSNVF PVFFQFLNIM VVGITGAAVV ITILKVFFPV SEYKGILQLD 300
KVDVIPVTAI NLYPDGPEKR AENLEDKTCI 330 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS