UniProt Accession

 SMD2_HUMAN; P62316; A8K797; J3KPM5; P43330 

Genbank Protein ID

 U15008; AK291912; AC007191; CH471126; CH471126; BC000486; BC001930; BU531743 

Genbank Nucleotide ID

 AAC13776.1; BAF84601.1; AAD22673.1; EAW57373.1; EAW57374.1; AAH00486.1; AAH01930.1 

Protein Name

 Small nuclear ribonucleoprotein Sm D2 

Protein Synonyms/Alias

 Sm-D2; snRNP core protein D2 

Gene Name

 SNRPD2 

Gene Synonyms/Alias

 SNRPD1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
6	**MSLLNKPKSEMTP	ubiquitination	[1]
8	MSLLNKPKSEMTPEE	sumoylation	[2]
8	MSLLNKPKSEMTPEE	ubiquitination	[1, 3]
18	MTPEELQKREEEEFN	ubiquitination	[1, 4]
57	KKLLGRVKAFDRHCN	ubiquitination	[1]
71	NMVLENVKEMWTEVP	ubiquitination	[1]
98	NKDRYISKMFLRGDS	ubiquitination	[1, 3, 5, 6]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif.
 Matic I, Schimmel J, Hendriks IA, van Santen MA, van de Rijke F, van Dam H, Gnad F, Mann M, Vertegaal AC.
 Mol Cell. 2010 Aug 27;39(4):641-52. [PMID: 20797634]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Required for pre-mRNA splicing. Required for snRNP biogenesis (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine.
 MOD_RES 12 12 Phosphothreonine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 118 AA 

Protein Sequence

Gene Ontology

 GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0030532; C:small nuclear ribonucleoprotein complex; TAS:ProtInc.
 GO:0005689; C:U12-type spliceosomal complex; IDA:UniProtKB.
 GO:0034660; P:ncRNA metabolic process; TAS:Reactome.
 GO:0000245; P:spliceosomal complex assembly; TAS:ProtInc.
 GO:0000387; P:spliceosomal snRNP assembly; TAS:Reactome. 

Interpro

 IPR010920; LSM_dom.
 IPR001163; Ribonucl_LSM.
 IPR006649; Ribonucl_LSM_euk/arc.
 IPR027248; Sm_D2. 

Pfam

 PF01423; LSM 

SMART

 SM00651; Sm 

PROSITE

  

PRINTS