CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025440
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Hepatocyte growth factor-regulated tyrosine kinase substrate 
Protein Synonyms/Alias
  
Gene Name
 Hgs 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
86VHDEVANKQTMEELKubiquitination[1]
93KQTMEELKELLKRQVubiquitination[1]
126FRNEPKYKVVQDTYQubiquitination[1]
146GHVFPEFKESDAMFAubiquitination[1]
221PCYEQLNKKAEGKASubiquitination[1]
472YYEGLQDKLAQIRDAubiquitination[1]
512RQIQLAQKLEIMRQKubiquitination[1]
520LEIMRQKKQEYLEVQubiquitination[1]
550QMRLEQQKQTVQMRAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 776 AA 
Protein Sequence
MGRGSGTFER LLDKATSQLL LETDWESILQ ICDLIRQGDT QAKYAVNSIK KKVNDKNPHV 60
ALYALEVMES VVKNCGQTVH DEVANKQTME ELKELLKRQV EVNVRNKILY LIQAWAHAFR 120
NEPKYKVVQD TYQIMKVEGH VFPEFKESDA MFAAERAPDW VDAEECHRCR VQFGVVTRKH 180
HCRACGQIFC GKCSSKYSTI PKFGIEKEVR VCEPCYEQLN KKAEGKASST TELPPEYLTS 240
PLSQQSQLPP KRDETALQEE EELQLALALS QSEAEEKERM RQKTTYTAHP KAEPTPLASS 300
APPAGSLYSS PVNSSAPLAE DIDPELARYL NRNYWEKKQE EARKSPTPSA PVPLTEPAAQ 360
PGEGHTAPNS MAEAPLPETD SQPITPCSGP FSEQYQNGES EESHEQFLKA LQNAVSTFVN 420
RMKSNHMRGR SITNDSAVLS LFQSINTMHP QLLELLNQLD ERRLYYEGLQ DKLAQIRDAR 480
GALSALREEH REKLRRAAEE AERQRQIQLA QKLEIMRQKK QEYLEVQRQL AIQRLQEQEK 540
ERQMRLEQQK QTVQMRAQMP AFPLPYAQLQ AMPTAGGVLY QPSGPTSFPA TFSPAGSVEG 600
SPMHGVYMSQ PAPATGPYPS MPGTTADPSM VSAYMYPTGA PGAQAAPQAQ AGPTTSPAYS 660
SYQPTPTPGY QSVASQAPQS LPAISQPPQT SNIGYMGSQP MSMGYQPYNM QNLMTALPGQ 720
DASLPAQQPY IPGQQPLYQQ MAPSTGPPQQ QPPVAQPAPT QGPPAQGSEA QLISFD 776 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005769; C:early endosome; IEA:Compara.
 GO:0016020; C:membrane; IEA:Compara.
 GO:0030141; C:secretory granule; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008333; P:endosome to lysosome transport; IEA:Compara.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0046426; P:negative regulation of JAK-STAT cascade; IEA:Compara. 
Interpro
 IPR008942; ENTH_VHS.
 IPR027426; HGS.
 IPR024641; HRS_helical.
 IPR017073; Ubi-bd_Hrs_VPS27.
 IPR003903; Ubiquitin-int_motif.
 IPR002014; VHS.
 IPR018205; VHS_subgr.
 IPR000306; Znf_FYVE.
 IPR017455; Znf_FYVE-rel.
 IPR011011; Znf_FYVE_PHD.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF01363; FYVE
 PF12210; Hrs_helical
 PF00790; VHS 
SMART
 SM00064; FYVE
 SM00726; UIM
 SM00288; VHS 
PROSITE
 PS50330; UIM
 PS50179; VHS
 PS50178; ZF_FYVE 
PRINTS