UniProt Accession

 HEMO_HUMAN; P02790; B2R957 

Genbank Protein ID

 M36803; M36796; M36799; M36800; M36801; M36802; AK313648; J03048; X02537 

Genbank Nucleotide ID

 AAA58678.1; AAA58678.1; AAA58678.1; AAA58678.1; AAA58678.1; AAA58678.1; BAG36404.1; AAA52704.1; CAA26382.1 

Protein Name

 Hemopexin 

Protein Synonyms/Alias

 Beta-1B-glycoprotein 

Gene Name

 HPX 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
115	VFLIKGDKVWVYPPE	glycation	[1]

Reference

 [1] Proteomic profiling of nonenzymatically glycated proteins in human plasma and erythrocyte membranes.
 Zhang Q, Tang N, Schepmoes AA, Phillips LS, Smith RD, Metz TO.
 J Proteome Res. 2008 May;7(5):2025-32. [PMID: 18396901] 

Functional Description

 Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. 

Sequence Annotation

 REPEAT 53 93 Hemopexin 1.
 REPEAT 94 139 Hemopexin 2.
 REPEAT 140 184 Hemopexin 3.
 REPEAT 185 231 Hemopexin 4.
 REPEAT 259 304 Hemopexin 5.
 REPEAT 305 352 Hemopexin 6.
 REPEAT 357 396 Hemopexin 7.
 REPEAT 400 450 Hemopexin 8.
 REGION 30 40 O-glycosylated at one site.
 METAL 79 79 Iron (heme 1 axial ligand) (By
 METAL 150 150 Iron (heme 1 axial ligand) (By
 METAL 236 236 Iron (heme 2 axial ligand) (By
 METAL 293 293 Iron (heme 2 axial ligand) (By
 CARBOHYD 24 24 O-linked (GalNAc...).
 CARBOHYD 29 29 O-linked (GalNAc...).
 CARBOHYD 64 64 N-linked (GlcNAc...) (complex).
 CARBOHYD 187 187 N-linked (GlcNAc...) (complex).
 CARBOHYD 240 240 N-linked (GlcNAc...).
 CARBOHYD 246 246 N-linked (GlcNAc...).
 CARBOHYD 453 453 N-linked (GlcNAc...) (complex).
 DISULFID 50 231
 DISULFID 149 154
 DISULFID 188 200
 DISULFID 257 460
 DISULFID 366 408
 DISULFID 418 435  

Keyword

 Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Heme; Host-virus interaction; Iron; Metal-binding; Polymorphism; Reference proteome; Repeat; Secreted; Signal; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 462 AA 

Protein Sequence

Gene Ontology

 GO:0071682; C:endocytic vesicle lumen; TAS:Reactome.
 GO:0005615; C:extracellular space; IDA:MGI.
 GO:0015232; F:heme transporter activity; TAS:ProtInc.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006879; P:cellular iron ion homeostasis; TAS:ProtInc.
 GO:0042168; P:heme metabolic process; IEA:Compara.
 GO:0020027; P:hemoglobin metabolic process; IEA:Compara.
 GO:0002925; P:positive regulation of humoral immune response mediated by circulating immunoglobulin; IEA:Compara.
 GO:0002639; P:positive regulation of immunoglobulin production; IEA:Compara.
 GO:0060335; P:positive regulation of interferon-gamma-mediated signaling pathway; IEA:Compara.
 GO:0042511; P:positive regulation of tyrosine phosphorylation of Stat1 protein; IEA:Compara.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR000585; Hemopexin-like_dom.
 IPR018487; Hemopexin-like_repeat.
 IPR016358; Hemopexin_chordata.
 IPR018486; Hemopexin_CS. 

Pfam

 PF00045; Hemopexin 

SMART

 SM00120; HX 

PROSITE

 PS00024; HEMOPEXIN
 PS51642; HEMOPEXIN_2 

PRINTS