UniProt Accession

 LMCD1_MOUSE; Q8VEE1 

Genbank Protein ID

 BC019124 

Genbank Nucleotide ID

 AAH19124.1 

Protein Name

 LIM and cysteine-rich domains protein 1 

Protein Synonyms/Alias

  

Gene Name

 Lmcd1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
6	**MAKVAKDLNPGVQ	acetylation	[1]
14	DLNPGVQKMSLGQQQ	acetylation	[1]

Reference

 [1] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

 Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue- specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter. Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway. 

Sequence Annotation

 DOMAIN 99 206 PET.
 DOMAIN 241 306 LIM zinc-binding 1.
 DOMAIN 307 365 LIM zinc-binding 2.  

Keyword

 Complete proteome; Cytoplasm; LIM domain; Metal-binding; Nucleus; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 365 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0031012; C:extracellular matrix; IEA:Compara.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003714; F:transcription corepressor activity; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IGI:MGI.
 GO:0070886; P:positive regulation of calcineurin-NFAT signaling cascade; IMP:UniProtKB.
 GO:0010611; P:regulation of cardiac muscle hypertrophy; IMP:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR010442; PET_domain.
 IPR001781; Znf_LIM. 

Pfam

 PF00412; LIM
 PF06297; PET 

SMART

 SM00132; LIM 

PROSITE

 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2
 PS51303; PET 

PRINTS