| Tag | Content |
|---|
| CPLM ID | CPLM-020352 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Lysine-specific demethylase 5D |
Protein Synonyms/Alias | Histocompatibility Y antigen; H-Y; Histone demethylase JARID1D; Jumonji/ARID domain-containing protein 1D; Protein SmcY |
Gene Name | KDM5D |
Gene Synonyms/Alias | HY; HYA; JARID1D; KIAA0234; SMCY |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 130 | GGYEAICKDRRWARV | ubiquitination | [1] | | 205 | RQSVQPSKFSSYSRR | ubiquitination | [1] | | 235 | EKHPELKKLQIYGPG | ubiquitination | [1] | | 287 | NVSSTLLKQHLSLEP | ubiquitination | [1] | | 360 | RGIWRCPKCILAECK | ubiquitination | [1] | | 708 | LRKALLEKGVTEAER | ubiquitination | [1] | | 785 | PTMLHKLKIRAESFD | ubiquitination | [1] | | 986 | ASSPSVDKARAELQE | ubiquitination | [1] | | 1004 | IAERWEEKAHFCLEA | ubiquitination | [1] | | 1041 | LPNIQALKEALTKAQ | ubiquitination | [1] | | 1312 | GWQDRARKALASEDV | ubiquitination | [1] | | 1336 | LRQQLQAKPRPEEAS | ubiquitination | [1] | | 1457 | RTLLELEKFEHQGSR | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. |
Sequence Annotation | DOMAIN 14 55 JmjN.
DOMAIN 79 169 ARID.
DOMAIN 458 624 JmjC.
ZN_FING 316 362 PHD-type 1.
ZN_FING 1174 1235 PHD-type 2.
METAL 504 504 Iron; catalytic (By similarity).
METAL 507 507 Iron; catalytic (By similarity).
METAL 592 592 Iron; catalytic (By similarity). |
Keyword | 3D-structure; Alternative splicing; Chromatin regulator; Complete proteome; Dioxygenase; Iron; Metal-binding; Nucleus; Oxidoreductase; Polymorphism; Reference proteome; Repeat; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1539 AA |
Protein Sequence | MEPGCDEFLP PPECPVFEPS WAEFQDPLGY IAKIRPIAEK SGICKIRPPA DWQPPFAVEV 60
DNFRFTPRVQ RLNELEAQTR VKLNYLDQIA KFWEIQGSSL KIPNVERKIL DLYSLSKIVI 120
EEGGYEAICK DRRWARVAQR LHYPPGKNIG SLLRSHYERI IYPYEMFQSG ANHVQCNTHP 180
FDNEVKDKEY KPHSIPLRQS VQPSKFSSYS RRAKRLQPDP EPTEEDIEKH PELKKLQIYG 240
PGPKMMGLGL MAKDKDKTVH KKVTCPPTVT VKDEQSGGGN VSSTLLKQHL SLEPCTKTTM 300
QLRKNHSSAQ FIDSYICQVC SRGDEDDKLL FCDGCDDNYH IFCLLPPLPE IPRGIWRCPK 360
CILAECKQPP EAFGFEQATQ EYSLQSFGEM ADSFKSDYFN MPVHMVPTEL VEKEFWRLVS 420
SIEEDVTVEY GADIHSKEFG SGFPVSNSKQ NLSPEEKRQS LTVLTRLISS FWAQAVLPPW 480
PPKVLGLQEY ATSGWNLNVM PVLDQSVLCH INADISGMKV PWLYVGMVFS AFCWHIEDHW 540
SYSINYLHWG EPKTWYGVPS LAAEHLEEVM KMLTPELFDS QPDLLHQLVT LMNPNTLMSH 600
GVPVVRTNQC AGEFVITFPR AYHSGFNQGY NFAEAVNFCT ADWLPAGRQC IEHYRRLRRY 660
CVFSHEELIC KMAAFPETLD LNLAVAVHKE MFIMVQEERR LRKALLEKGV TEAEREAFEL 720
LPDDERQCIK CKTTCFLSAL ACYDCPDGLV CLSHINDLCK CSSSRQYLRY RYTLDELPTM 780
LHKLKIRAES FDTWANKVRV ALEVEDGRKR SFEELRALES EARERRFPNS ELLQRLKNCL 840
SEVEACIAQV LGLVSGQVAR MDTPQLTLTE LRVLLEQMGS LPCAMHQIGD VKDVLEQVEA 900
YQAEAREALA TLPSSPGLLR SLLERGQQLG VEVPEAHQLQ QQVEQAQWLD EVKQALAPSA 960
HRGSLVIMQG LLVMGAKIAS SPSVDKARAE LQELLTIAER WEEKAHFCLE ARQKHPPATL 1020
EAIIRETENI PVHLPNIQAL KEALTKAQAW IADVDEIQNG DHYPCLDDLE GLVAVGRDLP 1080
VGLEELRQLE LQVLTAHSWR EKASKTFLKK NSCYTLLEVL CPCADAGSDS TKRSRWMEKA 1140
LGLYQCDTEL LGLSAQDLRD PGSVIVAFKE GEQKEKEGIL QLRRTNSAKP SPLAPSLMAS 1200
SPTSICVCGQ VPAGVGVLQC DLCQDWFHGQ CVSVPHLLTS PKPSLTSSPL LAWWEWDTKF 1260
LCPLCMRSRR PRLETILALL VALQRLPVRL PEGEALQCLT ERAIGWQDRA RKALASEDVT 1320
ALLRQLAELR QQLQAKPRPE EASVYTSATA CDPIREGSGN NISKVQGLLE NGDSVTSPEN 1380
MAPGKGSDLE LLSSLLPQLT GPVLELPEAI RAPLEELMME GDLLEVTLDE NHSIWQLLQA 1440
GQPPDLDRIR TLLELEKFEH QGSRTRSRAL ERRRRRQKVD QGRNVENLVQ QELQSKRARS 1500
SGIMSQVGRE EEHYQEKADR ENMFLTPSTD HSPFLKGNQN SLQHKDSGSS AACPSLMPLL 1560
QLSYSDEQQL 1570 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003677; F:DNA binding; IEA:InterPro. GO:0032453; F:histone demethylase activity (H3-K4 specific); IDA:MGI. GO:0016706; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; IEA:InterPro. GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:UniProtKB-KW. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0007283; P:spermatogenesis; NAS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |