UniProt Accession

 SC5A8_MOUSE; Q8BYF6; Q8VD01 

Genbank Protein ID

 AY484428; AK039927; BC017691 

Genbank Nucleotide ID

 AAS49159.1; BAC30480.1; AAH17691.1 

Protein Name

 Sodium-coupled monocarboxylate transporter 1 

Protein Synonyms/Alias

 Electrogenic sodium monocarboxylate cotransporter; Solute carrier family 5 member 8 

Gene Name

 Slc5a8 

Gene Synonyms/Alias

 Smct; Smct1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
558	DPRFLLTKQDFLSNF	ubiquitination	[1]
569	LSNFDVFKKRNHVLN	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D- hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D- lactate and monocarboxylate drugs from the intestinal tract. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons. 

Sequence Annotation

 CARBOHYD 485 485 N-linked (GlcNAc...) (Potential).  

Keyword

 Apoptosis; Cell membrane; Complete proteome; Glycoprotein; Ion transport; Membrane; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport; Tumor suppressor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 611 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW. 

Interpro

 IPR001734; Na/solute_symporter.
 IPR019900; Na/solute_symporter_subgr. 

Pfam

 PF00474; SSF 

SMART

  

PROSITE

 PS00456; NA_SOLUT_SYMP_1
 PS00457; NA_SOLUT_SYMP_2
 PS50283; NA_SOLUT_SYMP_3 

PRINTS