| Tag | Content |
|---|
| CPLM ID | CPLM-007903 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | U3 small nucleolar RNA-associated protein MPP10 |
Protein Synonyms/Alias | U3 snoRNA-associated protein MPP10; M phase phosphoprotein 10 |
Gene Name | MPP10 |
Gene Synonyms/Alias | YJR002W; J1411; YJR83.5 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 18 | NAGRIILKDPSATSK | acetylation | [1] | | 309 | KQQIEIRKQIEQLEN | acetylation | [1] | | 322 | ENEAVAEKKWSLKGE | acetylation | [1] | | 333 | LKGEVKAKDRPEDAL | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Involved in nucleolar processing of pre-18S ribosomal RNA. Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing. |
Sequence Annotation | MOD_RES 176 176 Phosphoserine.
MOD_RES 177 177 Phosphoserine.
MOD_RES 181 181 Phosphotyrosine. |
Keyword | Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosome biogenesis; rRNA processing. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 593 AA |
Protein Sequence | MSELFGVLKS NAGRIILKDP SATSKDVKAY IDSVINTCKN GSITKKAELD EITVDGLDAN 60
QVWWQVKLVL DSIDGDLIQG IQELKDVVTP SHNLSDGSTL NSSSGEESEL EEAESVFKEK 120
QMLSADVSEI EEQSNDSLSE NDEEPSMDDE KTSAEAAREE FAEEKRISSG QDERHSSPDP 180
YGINDKFFDL EKFNRDTLAA EDSNEASEGS EDEDIDYFQD MPSDDEEEEA IYYEDFFDKP 240
TKEPVKKHSD VKDPKEDEEL DEEEHDSAMD KVKLDLFADE EDEPNAEGVG EASDKNLSSF 300
EKQQIEIRKQ IEQLENEAVA EKKWSLKGEV KAKDRPEDAL LTEELEFDRT AKPVPVITSE 360
VTESLEDMIR RRIQDSNFDD LQRRTLLDIT RKSQRPQFEL SDVKSSKSLA EIYEDDYTRA 420
EDESALSEEL QKAHSEISEL YANLVYKLDV LSSVHFVPKP ASTSLEIRVE TPTISMEDAQ 480
PLYMSNASSL APQEIYNVGK AEKDGEIRLK NGVAMSKEEL TREDKNRLRR ALKRKRSKAN 540
LPNVNKRSKR NDVVDTLSKA KNITVINQKG EKKDVSGKTK KSRSGPDSTN IKL 593 |
Gene Ontology | GO:0034457; C:Mpp10 complex; IDA:SGD. GO:0032040; C:small-subunit processome; IDA:SGD. GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD. GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD. GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD. |
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