| Tag | Content |
|---|
| CPLM ID | CPLM-018523 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Arsenite methyltransferase |
Protein Synonyms/Alias | Methylarsonite methyltransferase; S-adenosyl-L-methionine:arsenic(III) methyltransferase |
Gene Name | As3mt |
Gene Synonyms/Alias | Cyt19 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 12 | RDADEIHKDVQNYYG | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity). |
Sequence Annotation | |
Keyword | Complete proteome; Cytoplasm; Methyltransferase; Reference proteome; S-adenosyl-L-methionine; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 376 AA |
Protein Sequence | MAASRDADEI HKDVQNYYGN VLKTSADLQT NACVTRAKPV PSYIRESLQN VHEDVSSRYY 60
GCGLTVPERL ENCRILDLGS GSGRDCYVLS QLVGEKGHVT GIDMTEVQVE VAKTYLEHHM 120
EKFGFQAPNV TFLHGRIEKL AEAGIQSESY DIVISNCVIN LVPDKQQVLQ EVYRVLKHGG 180
ELYFSDVYAS LEVPEDIKSH KVLWGECLGG ALYWKDLAII AQKIGFCPPR LVTADIITVE 240
NKELEGVLGD CRFVSATFRL FKLPKTEPAE RCRVVYNGGI KGHEKELIFD ANFTFKEGEA 300
VAVDEETAAV LKNSRFAPDF LFTPVDASLP APQGRSELET KVLIRDPFKL AEDSDKMKPR 360
HAPEGTGGCC GKRKNC 376 |
Gene Ontology | GO:0005829; C:cytosol; ISS:UniProtKB. GO:0005739; C:mitochondrion; IDA:MGI. GO:0030791; F:arsenite methyltransferase activity; ISS:UniProtKB. GO:0030792; F:methylarsonite methyltransferase activity; ISS:UniProtKB. GO:0018872; P:arsonoacetate metabolic process; ISS:UniProtKB. GO:0046685; P:response to arsenic-containing substance; ISA:MGI. GO:0009404; P:toxin metabolic process; ISS:UniProtKB. |
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