CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039996
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Transferrin receptor protein 1, serum form 
Protein Synonyms/Alias
  
Gene Name
 TFRC 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
62ISRAAAEKLFGNMEGubiquitination[1, 2]
76GDCPSDWKTDSTCRMubiquitination[1, 2]
92TSESKNVKLTVSNVLubiquitination[2]
100LTVSNVLKEIKILNIubiquitination[1, 2, 3]
103SNVLKEIKILNIFGVubiquitination[2]
112LNIFGVIKGFVEPDHacetylation[4]
112LNIFGVIKGFVEPDHubiquitination[5]
136AWGPGAAKSGVGTALubiquitination[1, 2, 3, 5, 6]
204FTYINLDKAVLGTSNubiquitination[2]
213VLGTSNFKVSASPLLubiquitination[1]
232EKTMQNVKHPVTGQFacetylation[4]
232EKTMQNVKHPVTGQFubiquitination[1, 2]
249QDSNWASKVEKLTLDubiquitination[1, 2, 3]
252NWASKVEKLTLDNAAubiquitination[2]
303ERIPELNKVARAAAEubiquitination[1, 2]
383TDFGNAEKTDRFVMKubiquitination[2, 3]
411LSPYVSPKESPFRHVubiquitination[1, 2, 3, 6]
435PALLENLKLRKQNNGubiquitination[1, 2]
438LENLKLRKQNNGAFNubiquitination[2]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Monoclonal antibody cocktail as an enrichment tool for acetylome analysis.
 Shaw PG, Chaerkady R, Zhang Z, Davidson NE, Pandey A.
 Anal Chem. 2011 May 15;83(10):3623-6. [PMID: 21466224]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 478 AA 
Protein Sequence
MDQTKFPIVN AELSFFGHAH LGTGDPYTPG FPSFNHTQFP PSRSSGLPNI PVQTISRAAA 60
EKLFGNMEGD CPSDWKTDST CRMVTSESKN VKLTVSNVLK EIKILNIFGV IKGFVEPDHY 120
VVVGAQRDAW GPGAAKSGVG TALLLKLAQM FSDMVLKDGF QPSRSIIFAS WSAGDFGSVG 180
ATEWLEGYLS SLHLKAFTYI NLDKAVLGTS NFKVSASPLL YTLIEKTMQN VKHPVTGQFL 240
YQDSNWASKV EKLTLDNAAF PFLAYSGIPA VSFCFCEDTD YPYLGTTMDT YKELIERIPE 300
LNKVARAAAE VAGQFVIKLT HDVELNLDYE RYNSQLLSFV RDLNQYRADI KEMGLSLQWL 360
YSARGDFFRA TSRLTTDFGN AEKTDRFVMK KLNDRVMRVE YHFLSPYVSP KESPFRHVFW 420
GSGSHTLPAL LENLKLRKQN NGAFNETLFR NQLALATWTI QGAANALSGD VWDIDNEF 478 
Gene Ontology
 GO:0005768; C:endosome; IEA:Compara.
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0070062; C:extracellular vesicular exosome; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0008233; F:peptidase activity; IEA:InterPro.
 GO:0006879; P:cellular iron ion homeostasis; IEA:Compara.
 GO:0030316; P:osteoclast differentiation; IEA:Compara.
 GO:0045780; P:positive regulation of bone resorption; IEA:Compara.
 GO:0006508; P:proteolysis; IEA:InterPro. 
Interpro
 IPR007484; Peptidase_M28.
 IPR007365; TFR-like_dimer_dom. 
Pfam
 PF04389; Peptidase_M28
 PF04253; TFR_dimer 
SMART
  
PROSITE
  
PRINTS