UniProt Accession

 PTRF_RAT; P85125 

Genbank Protein ID

  

Genbank Nucleotide ID

  

Protein Name

 Polymerase I and transcript release factor 

Protein Synonyms/Alias

 Cavin-1; cav-p60 

Gene Name

 Ptrf 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
100	GELSKLGKAHATTSN	ubiquitination	[1]
111	TTSNTVSKLLEKVRK	ubiquitination	[1]
163	MIYQDEVKLPAKLSV	ubiquitination	[1]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Plays an important role in caveolae formation and organization. Required for the sequestration of mobile caveolin into immobile caveolae. Termination of transcription by RNA polymerase I involves pausing of transcription by TTF1, and the dissociation of the transcription complex, releasing pre-rRNA and RNA polymerase I from the template. PTRF is required for dissociation of the ternary transcription complex (By similarity). 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 38 38 Phosphoserine (By similarity).
 MOD_RES 40 40 Phosphothreonine (By similarity).
 MOD_RES 42 42 Phosphoserine (By similarity).
 MOD_RES 169 169 Phosphoserine (By similarity).
 MOD_RES 177 177 Phosphoserine (By similarity).
 MOD_RES 204 204 Phosphoserine (By similarity).
 MOD_RES 205 205 Phosphoserine (By similarity).
 MOD_RES 302 302 Phosphoserine (By similarity).
 MOD_RES 304 304 Phosphothreonine (By similarity).
 MOD_RES 367 367 Phosphoserine (By similarity).
 MOD_RES 368 368 Phosphoserine (By similarity).
 MOD_RES 389 389 Phosphoserine (By similarity).
 MOD_RES 391 391 Phosphoserine (By similarity).  

Keyword

 Acetylation; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Endoplasmic reticulum; Membrane; Microsome; Mitochondrion; Nucleus; Phosphoprotein; Reference proteome; RNA-binding; rRNA-binding; Transcription; Transcription regulation; Transcription termination. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 392 AA 

Protein Sequence

Gene Ontology

 GO:0005901; C:caveola; IDA:UniProtKB.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; ISS:UniProtKB.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0042134; F:rRNA primary transcript binding; ISS:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006363; P:termination of RNA polymerase I transcription; ISS:UniProtKB.
 GO:0006361; P:transcription initiation from RNA polymerase I promoter; ISS:UniProtKB. 

Interpro

 IPR026752; Cavin_fam. 

Pfam

  

SMART

  

PROSITE

  

PRINTS