UniProt Accession

 RXT2_YEAST; P38255; D6VQ96 

Genbank Protein ID

 X69881; X78993; Z35964; AY692685; BK006936 

Genbank Nucleotide ID

 CAA49507.1; CAA55600.1; CAA85048.1; AAT92704.1; DAA07216.1 

Protein Name

 Transcriptional regulatory protein RXT2 

Protein Synonyms/Alias

  

Gene Name

 RXT2 

Gene Synonyms/Alias

 RAF60; YBR095C; YBR0822 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
45	SGNYQVLKRSLDGKL	acetylation	[1]
51	LKRSLDGKLIYPEAT	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. 

Sequence Annotation

  

Keyword

 Chromatin regulator; Complete proteome; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 430 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:SGD.
 GO:0033698; C:Rpd3L complex; IDA:SGD.
 GO:0070210; C:Rpd3L-Expanded complex; IDA:SGD.
 GO:0000747; P:conjugation with cellular fusion; IMP:SGD.
 GO:0016575; P:histone deacetylation; IMP:GOC.
 GO:0001403; P:invasive growth in response to glucose limitation; IMP:SGD.
 GO:0061188; P:negative regulation of chromatin silencing at rDNA; IMP:SGD.
 GO:0061186; P:negative regulation of chromatin silencing at silent mating-type cassette; IMP:SGD.
 GO:0031939; P:negative regulation of chromatin silencing at telomere; IMP:SGD.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:SGD.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR013904; RXT2_N. 

Pfam

 PF08595; RXT2_N 

SMART

  

PROSITE

  

PRINTS