CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021403
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DNA transposase THAP9 
Protein Synonyms/Alias
 THAP domain-containing protein 9; hTh9 
Gene Name
 THAP9 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
667DISIARRKDLALWTVmethylation[1]
890SFANTSSKFRHLLSNubiquitination[2]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Active transposase that specifically recognizes the bipartite 5'-TXXGGGX(A/T)-3' consensus motif and mediates transposition. 
Sequence Annotation
 ZN_FING 1 89 THAP-type.
 MOTIF 123 126 HCFC1-binding motif (HBM) (By  
Keyword
 Complete proteome; DNA integration; DNA recombination; DNA-binding; Metal-binding; Polymorphism; Reference proteome; Transferase; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 903 AA 
Protein Sequence
MTRSCSAVGC STRDTVLSRE RGLSFHQFPT DTIQRSKWIR AVNRVDPRSK KIWIPGPGAI 60
LCSKHFQESD FESYGIRRKL KKGAVPSVSL YKIPQGVHLK GKARQKILKQ PLPDNSQEVA 120
TEDHNYSLKT PLTIGAEKLA EVQQMLQVSK KRLISVKNYR MIKKRKGLRL IDALVEEKLL 180
SEETECLLRA QFSDFKWELY NWRETDEYSA EMKQFACTLY LCSSKVYDYV RKILKLPHSS 240
ILRTWLSKCQ PSPGFNSNIF SFLQRRVENG DQLYQYCSLL IKSMPLKQQL QWDPSSHSLQ 300
GFMDFGLGKL DADETPLASE TVLLMAVGIF GHWRTPLGYF FVNRASGYLQ AQLLRLTIGK 360
LSDIGITVLA VTSDATAHSV QMAKALGIHI DGDDMKCTFQ HPSSSSQQIA YFFDSCHLLR 420
LIRNAFQNFQ SIQFINGIAH WQHLVELVAL EEQELSNMER IPSTLANLKN HVLKVNSATQ 480
LFSESVASAL EYLLSLDLPP FQNCIGTIHF LRLINNLFDI FNSRNCYGKG LKGPLLPETY 540
SKINHVLIEA KTIFVTLSDT SNNQIIKGKQ KLGFLGFLLN AESLKWLYQN YVFPKVMPFP 600
YLLTYKFSHD HLELFLKMLR QVLVTSSSPT CMAFQKAYYN LETRYKFQDE VFLSKVSIFD 660
ISIARRKDLA LWTVQRQYGV SVTKTVFHEE GICQDWSHCS LSEALLDLSD HRRNLICYAG 720
YVANKLSALL TCEDCITALY ASDLKASKIG SLLFVKKKNG LHFPSESLCR VINICERVVR 780
THSRMAIFEL VSKQRELYLQ QKILCELSGH INLFVDVNKH LFDGEVCAIN HFVKLLKDII 840
ICFLNIRAKN VAQNPLKHHS ERTDMKTLSR KHWSSVQDYK CSSFANTSSK FRHLLSNDGY 900
PFK 903 
Gene Ontology
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
 GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
 GO:0004803; F:transposase activity; IDA:UniProtKB.
 GO:0015074; P:DNA integration; IDA:UniProtKB.
 GO:0006313; P:transposition, DNA-mediated; IDA:UniProtKB. 
Interpro
 IPR006612; Znf_C2CH. 
Pfam
 PF05485; THAP 
SMART
 SM00692; DM3
 SM00980; THAP 
PROSITE
 PS50950; ZF_THAP 
PRINTS