CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013184
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 4-hydroxythreonine-4-phosphate dehydrogenase 
Protein Synonyms/Alias
 4-(phosphohydroxy)-L-threonine dehydrogenase 
Gene Name
 pdxA 
Gene Synonyms/Alias
 RPA3065 
Created Date
 July 27, 2013 
Organism
 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) 
NCBI Taxa ID
 258594 
Lysine Modification
Position
Peptide
Type
References
126VVTNPIAKSVLYQAGacetylation[1]
Reference
 [1] System-wide studies of N-lysine acetylation in Rhodopseudomonas palustris reveal substrate specificity of protein acetyltransferases.
 Crosby HA, Pelletier DA, Hurst GB, Escalante-Semerena JC.
 J Biol Chem. 2012 May 4;287(19):15590-601. [PMID: 22416131] 
Functional Description
 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity). 
Sequence Annotation
 METAL 173 173 Divalent metal cation; shared with
 METAL 218 218 Divalent metal cation; shared with
 METAL 273 273 Divalent metal cation; shared with
 BINDING 139 139 Substrate (By similarity).
 BINDING 140 140 Substrate (By similarity).
 BINDING 281 281 Substrate (By similarity).
 BINDING 290 290 Substrate (By similarity).
 BINDING 299 299 Substrate (By similarity).  
Keyword
 Cobalt; Complete proteome; Cytoplasm; Magnesium; Metal-binding; NAD; NADP; Oxidoreductase; Pyridoxine biosynthesis; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 337 AA 
Protein Sequence
MTGMAKPLAL TLGEPAGIGP DIALAAWLKR EQHGLPPFYL LGDAGCLSRC AKLLGLDVPL 60
AEVKAEDAAA AFATTLPVVS TGQIATATPG QPDATSAPAA IASIEHAVAD VRSGRAAAVV 120
TNPIAKSVLY QAGFHHPGHT EFLAELAKRD GIVPQPVMML WCPALAVVPV TIHVSLRDAI 180
TQLTTDLIVS TARIVVKDLR ERLGIAQPRL ALAGLNPHAG EDGALGQEDR AVVAPAVAIL 240
RREGVDARGP LPADTMFHAA ARKTYDCAIC MYHDQALIPI KTIAFDEGVN VTLGLPFIRT 300
SPDHGTAFDI AGSGQANPSS LIAALKLAAQ MASAKTA 337 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0050570; F:4-hydroxythreonine-4-phosphate dehydrogenase activity; IEA:HAMAP.
 GO:0050897; F:cobalt ion binding; IEA:HAMAP.
 GO:0000287; F:magnesium ion binding; IEA:HAMAP.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:HAMAP.
 GO:0042823; P:pyridoxal phosphate biosynthetic process; IEA:HAMAP.
 GO:0008615; P:pyridoxine biosynthetic process; IEA:HAMAP. 
Interpro
 IPR024084; IsoPropMal-DH-like_dom.
 IPR005255; PdxA. 
Pfam
 PF04166; PdxA 
SMART
  
PROSITE
  
PRINTS