UniProt Accession

 CYTA_HUMAN; P01040 

Genbank Protein ID

 X05978; D88422; AB007774; BC010379 

Genbank Nucleotide ID

 CAA29398.1; BAA13609.1; BAA87858.1; AAH10379.1 

Protein Name

 Cystatin-A 

Protein Synonyms/Alias

 Cystatin-AS; Stefin-A; Cystatin-A, N-terminally processed 

Gene Name

 CSTA 

Gene Synonyms/Alias

 STF1; STFA 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
37	KTNETYGKLEAVQYK	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis. 

Sequence Annotation

 MOTIF 46 50 Secondary area of contact.
 MOD_RES 1 1 N-acetylmethionine (By similarity).  

Keyword

 3D-structure; Acetylation; Cell adhesion; Complete proteome; Cytoplasm; Direct protein sequencing; Ichthyosis; Polymorphism; Protease inhibitor; Reference proteome; Thiol protease inhibitor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 98 AA 

Protein Sequence

Gene Ontology

 GO:0001533; C:cornified envelope; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IDA:BHF-UCL.
 GO:0030674; F:protein binding, bridging; IDA:UniProtKB.
 GO:0005198; F:structural molecule activity; IDA:UniProtKB.
 GO:0016337; P:cell-cell adhesion; IMP:UniProtKB.
 GO:0030216; P:keratinocyte differentiation; IDA:UniProtKB.
 GO:0018149; P:peptide cross-linking; IDA:UniProtKB. 

Interpro

 IPR000010; Prot_inh_cystat.
 IPR018073; Prot_inh_cystat_CS.
 IPR001713; Prot_inh_stefinA. 

Pfam

 PF00031; Cystatin 

SMART

 SM00043; CY 

PROSITE

 PS00287; CYSTATIN 

PRINTS

 PR00295; STEFINA.