| Tag | Content |
|---|
| CPLM ID | CPLM-008119 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Heparin cofactor 2 |
Protein Synonyms/Alias | Heparin cofactor II; HC-II; Protease inhibitor leuserpin-2; Serpin D1 |
Gene Name | Serpind1 |
Gene Synonyms/Alias | Hcf2; Hcii |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 380 | LPKFKLEKNYNLVEV | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. |
Sequence Annotation | REPEAT 54 64 1.
REPEAT 68 78 2.
REGION 54 78 2 X 11 AA approximate repeats, Asp/Glu-
REGION 171 191 Glycosaminoglycan-binding site (By
MOD_RES 60 60 Sulfotyrosine (By similarity).
MOD_RES 73 73 Sulfotyrosine (By similarity).
CARBOHYD 30 30 N-linked (GlcNAc...).
CARBOHYD 167 167 N-linked (GlcNAc...).
CARBOHYD 366 366 N-linked (GlcNAc...) (Potential).
CARBOHYD 402 402 N-linked (GlcNAc...) (Potential). |
Keyword | Blood coagulation; Complete proteome; Direct protein sequencing; Glycoprotein; Hemostasis; Heparin-binding; Protease inhibitor; Reference proteome; Repeat; Serine protease inhibitor; Signal; Sulfation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 478 AA |
Protein Sequence | MKHPLCTLLS LITFMCIGSK GLAEQLTNEN LTTSFLPANF HKENTVTNDW IPEGEEDEDY 60
LDLEKLLGED DDYIYIIDAV SPTDSESSAG NILQLFQGKS RIQRLNILNA KFAFNLYRVL 120
KDQATTSDNL FIAPVGISTA MGMISLGLRG ETHEEVHSVL HFRDFVNASS KYEVTTIHNL 180
FRKLTHRLFR RNFGYTLRSV NGLYIQKQFP IREDFKAAMR EFYFAEAQEA NFPDPAFISK 240
ANNHILKLTK GLIKEALENI DPATQMLILN CIYFKGTWVN KFPVEMTHNH NFRLNEREVV 300
KVSMMQTKGN FLAANDQELD CDILQLEYVG GISMLIVVPR KLSGMKTLEA QLTPQVVERW 360
QKSMTNRTRE VLLPKFKLEK NYNLVEVLKS MGITKLFNKN GNMSGISDQR IAIDLFKHQS 420
TITVNEEGTQ AAAVTTVGFM PLSTQVRFTV DRPFLFLVYE HRTSCLLFMG KVTNPAKS 478 |
Gene Ontology | GO:0008201; F:heparin binding; IEA:UniProtKB-KW. GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:RefGenome. GO:0007596; P:blood coagulation; IEA:UniProtKB-KW. GO:0030162; P:regulation of proteolysis; IBA:RefGenome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |