UniProt Accession

 DHI1_MOUSE; P50172 

Genbank Protein ID

 S75207; X83202; X92186 

Genbank Nucleotide ID

 AAB33601.1; CAA58209.1; CAA63096.1 

Protein Name

 Corticosteroid 11-beta-dehydrogenase isozyme 1 

Protein Synonyms/Alias

 11-beta-hydroxysteroid dehydrogenase 1; 11-DH; 11-beta-HSD1; 11beta-HSD1A 

Gene Name

 Hsd11b1 

Gene Synonyms/Alias

 Hsd11 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
44	VIVTGASKGIGREMA	ubiquitination	[1]
73	RSEEGLQKVVSRCLE	ubiquitination	[1]
260	KSEVYYDKSPLTPIL	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. 

Sequence Annotation

 NP_BIND 41 67 NADP.
 NP_BIND 92 93 NADP.
 NP_BIND 119 121 NADP.
 NP_BIND 183 187 NADP.
 NP_BIND 216 222 NADP.
 ACT_SITE 183 183 Proton acceptor.
 BINDING 170 170 Substrate.
 CARBOHYD 162 162 N-linked (GlcNAc...) (Potential).
 CARBOHYD 207 207 N-linked (GlcNAc...) (Potential).  

Keyword

 3D-structure; Complete proteome; Endoplasmic reticulum; Glycoprotein; Lipid metabolism; Membrane; NADP; Oxidoreductase; Reference proteome; Signal-anchor; Steroid metabolism; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 292 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0070524; F:11-beta-hydroxysteroid dehydrogenase (NADP+) activity; IEA:EC.
 GO:0003845; F:11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity; IDA:MGI.
 GO:0030324; P:lung development; IMP:MGI.
 GO:0008202; P:steroid metabolic process; IEA:UniProtKB-KW. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.